Antimicrobial and Antiproliferative Prospective of Kosinostatin - a Secondary Metabolite Isolated from Sp

Overview

Journal J Pharm Anal

Specialty Chemistry

Date 2018 Feb 7

PMID 29403952

Citations 6

Authors

Vinayagam Rambabu

Subramaniyan Suba

Suburamaniyan Vijayakumar

Affiliations

Soon will be listed here.

Abstract

Cancer is a communal health hazard worldwide. The present investigation attempts to evaluate antimicrobial and anticancer potential of kosinostatin on mammary carcinoma cell line (MCF-7). The anticancer and antiproliferative activities of kosinostatin were analyzed on MCF cell line by MTT assay and cytotoxicity assays like lactate dehydrogenase (LDH) and glutathione (GSH). The secondary metabolite kosinostatin exhibited its apoptotic nature by expressing p53 protein. Collectively, the results acquired from this study promise that kosinostatin shows the potent anticancer activity.

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