» Articles » PMID: 29403303

The Clinicopathological Features of Patients with Membranous Nephropathy

Overview
Publisher Dove Medical Press
Specialty Nephrology
Date 2018 Feb 7
PMID 29403303
Citations 3
Authors
Affiliations
Soon will be listed here.
Abstract

Background: Membranous nephropathy (MN) represents a distinct glomerular disease which has been considered as a major cause of nephrotic syndrome (NS) in adults. Evidences show that the clinicopathological features of MN are various among MN cases. This study aimed to summarize and analyze the clinicopathological features of patients with MN.

Methods: A total of 231 MN patients were recruited in this study. Their clinical and pathological features were collected and analyzed according to their age, gender, pathological stages, and anti-phospholipase A2 receptor (anti-PLA2R) antibodies tests.

Results: Among the 231 MN cases, the ratio of male to female was 1.47 and the mean age was 47.43±14.32 years. Altogether, 163 (70.6%) cases were positive for NS. Their serum antiPLA2R, body mass index, total cholesterol, triglyceride, low density lipoprotein cholesterol, D2, IgA, and IgE were increased, but IgG was decreased. The majority of the patients were middle aged and old aged. In addition, the pathological stage was significantly correlated with gender (=0.038), creatinine, (=0.021) and IgE (=0.003). A total of 74.9% MN patients were found to be positive for anti-PLA2R antibodies, and they were more likely to have abnormal serum indices.

Conclusion: The major clinicopathological characteristics of MN patients are summarized in this study. Male and elder MN cases are likely to have rapid disease progression. Advanced pathological stages and being positive for anti-PLA2R antibodies may be potential indicators for disease activity of MN.

Citing Articles

Changes in the spectrum of kidney diseases: a survey of 2803 patients from 2010 to 2018 at a single center in southeastern China.

Zheng L, Tu L, Huang H, Zhang L, Wang Y, Zhou J Ren Fail. 2022; 44(1):987-993.

PMID: 35656734 PMC: 9176642. DOI: 10.1080/0886022X.2022.2083517.


The Diagnostic and Prognostic Potential of the B-Cell Repertoire in Membranous Nephropathy.

Su Z, Jin Y, Zhang Y, Guan Z, Li H, Chen X Front Immunol. 2021; 12:635326.

PMID: 34122405 PMC: 8190383. DOI: 10.3389/fimmu.2021.635326.


Clinical value of a serum anti-PLA2R antibody in the diagnosis and monitoring of primary membranous nephropathy in adults.

Wu X, Liu L, Guo Y, Yang L Int J Nephrol Renovasc Dis. 2018; 11:241-247.

PMID: 30288080 PMC: 6159797. DOI: 10.2147/IJNRD.S176665.

References
1.
Ponticelli C, Passerini P . Can prognostic factors assist therapeutic decisions in idiopathic membranous nephropathy?. J Nephrol. 2010; 23(2):156-63. View

2.
Praga M, Rojas-Rivera J . Glomerular disease: Predicting outcomes in idiopathic membranous nephropathy. Nat Rev Nephrol. 2012; 8(9):496-8. DOI: 10.1038/nrneph.2012.161. View

3.
Gandolfo M, Verzola D, Salvatore F, Gianiorio G, Procopio V, Romagnoli A . Gender and the progression of chronic renal diseases: does apoptosis make the difference?. Minerva Urol Nefrol. 2004; 56(1):1-14. View

4.
Cravedi P, Abbate M, Gagliardini E, Galbusera M, Buelli S, Sabadini E . Membranous nephropathy associated with IgG4-related disease. Am J Kidney Dis. 2011; 58(2):272-5. DOI: 10.1053/j.ajkd.2011.05.002. View

5.
Wang Y, Wang G, Li B, Chen Q . Clinicopathological analysis of idiopathic membranous nephropathy in young adults. Genet Mol Res. 2015; 14(2):4541-8. DOI: 10.4238/2015.May.4.12. View