Intra Nasal Gelling System of Lamotrigine Using Ion Activated Mucoadhesive Polymer

Overview

Journal Open Med Chem J

Publisher Bentham Open

Specialty Biochemistry

Date 2018 Feb 6

PMID 29399211

Citations 7

Authors

Asha Paul

K M Fathima

Sreeja C Nair

Affiliations

Soon will be listed here.

Abstract

Background: A novel drug delivery system for treating acute epileptic condition.

Objective: To develop an intranasal mucoadhesive formulation of Lamotrigine (LTG) loaded gel, for the treatment of epilepsy to avoid possible side effects and first pass metabolism associated with conventional treatment.

Methods: Lamotrigine was loaded into different polymeric solutions of gellan and xanthan gum.

Results: All formulations subjected to various evaluation studies were within their acceptable limits. The pH of formulation ranges between 5.8 ±.001 to 6.8 ±.005 indicating that no mucosal irritation is expected as pH was in acceptable range. drug release from the mucoadhesive gel formulations showed immediate drug release pattern with a maximum drug release of 97.02 ±0.54% for optimized G5 formulation within 20min. permeation studies of optimized formulation G5 and control formulation was estimated. permeation studies of G5 formulation done for a period of 12 h resulted in slow, sustained release and greater permeability significance(P <0.05) through nasal mucosa when compared to control. Histopathological studies showed that G5 formulation was safer for nasal administration without any irritation. The stability studies indicated that gels were stable over 45 days in refrigerated condition (4±2ºC).

Conclusion: The intranasal gelling system is a promising novel drug delivery system for an antiepileptic drug lamotrigine which could enhance nasal residence time with increased viscosity and mucoadhesive character and provided better release profile of drug for treating acute epileptic conditions.

Citing Articles

Recent opportunities and application of gellan gum based drug delivery system for intranasal route.

Garg A, Lavania K Daru. 2024; 32(2):947-965.

PMID: 39361194 PMC: 11555193. DOI: 10.1007/s40199-024-00543-w.

Lamotrigine-Loaded Poloxamer-Based Thermo-Responsive Sol-Gel: Formulation, In Vitro Assessment, Ex Vivo Permeation, and Toxicology Study.

Riaz M, Zaman M, Hameed H, Sarwar H, Khan M, Irfan A Gels. 2023; 9(10).

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New Biopharmaceutical Characteristics of In Situ Systems Based on Poloxamer 407.

Bakhrushina E, Novozhilova E, Shumkova M, Pyzhov V, Nikonenko M, Bardakov A Gels. 2023; 9(7).

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Ezike T, Okpala U, Onoja U, Nwike C, Ezeako E, Okpara O Heliyon. 2023; 9(6):e17488.

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Ion-Triggered In Situ Gelling Intranasal Spray of Dronedarone Hydrochloride Nanocarriers: In Vitro Optimization and In Vivo Pharmacokinetic Appraisal.

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