Cancer-associated Fibroblasts Regulate the Biological Behavior of Cancer Cells and Stroma in Gastric Cancer

Overview

Journal Oncol Lett

Specialty Oncology

Date 2018 Feb 6

PMID 29399141

Citations 20

Authors

Qian Zhang

Chunwei Peng

Affiliations

Soon will be listed here.

Abstract

Gastric cancer (GC) is a frequently diagnosed type of cancer in China, and is associated with a high mortality rate. The biological behavior of GC requires investigation in order to provide an evidence base for the development of strategies to prevent and treat GC. For this purpose, the present review outlines the process of tumor microenvironment (TME) evolution, including the dynamic biological behavior of different types of cancer cell and stroma. Cancer-associated fibroblasts (CAFs) serve as prominent stromal cellular components in the GC TME, and exhibit an essential function in GC progression. In the present study, the function of CAFs in cancer cell proliferation, cell migration, invasion, extracellular matrix remodeling, pathological angiogenesis and immune cell infiltration were investigated. The studies discussed in the present review demonstrate that the cross-talk between CAF, cancer cells and tumor stroma promotes GC progression.

Citing Articles

Role and value of the tumor microenvironment in the progression and treatment resistance of gastric cancer (Review).

Yun H, Dong F, Wei X, Yan X, Zhang R, Zhang X Oncol Rep. 2024; 53(1).

PMID: 39611496 PMC: 11622107. DOI: 10.3892/or.2024.8847.

Influence of Tumor Stroma on the Aggressiveness of Poorly Cohesive Gastric Carcinoma.

Malpeli G, Filippini F, Tedone F, Torroni L, Alloggio M, Castelli C J Pers Med. 2024; 14(2).

PMID: 38392627 PMC: 10890005. DOI: 10.3390/jpm14020194.

Theranostic signature of tumor-derived exosomes in cancer.

Kumar S, Dhar R, Kumar L, Shivji G, Jayaraj R, Devi A Med Oncol. 2023; 40(11):321.

PMID: 37798480 DOI: 10.1007/s12032-023-02176-6.

"DEPHENCE" system-a novel regimen of therapy that is urgently needed in the high-grade serous ovarian cancer-a focus on anti-cancer stem cell and anti-tumor microenvironment targeted therapies.

Wilczynski J, Wilczynski M, Paradowska E Front Oncol. 2023; 13:1201497.

PMID: 37448521 PMC: 10338102. DOI: 10.3389/fonc.2023.1201497.

Exosomes in metastasis of colorectal cancers: Friends or foes?.

Wu Z, Fang Z, Hou Y, Wu B, Deng Y, Wu H World J Gastrointest Oncol. 2023; 15(5):731-756.

PMID: 37275444 PMC: 10237026. DOI: 10.4251/wjgo.v15.i5.731.

References

Sun C, Fukui H, Hara K, Zhang X, Kitayama Y, Eda H . FGF9 from cancer-associated fibroblasts is a possible mediator of invasion and anti-apoptosis of gastric cancer cells. BMC Cancer. 2015; 15:333. PMC: 4424580. DOI: 10.1186/s12885-015-1353-3. View

Poon R, Fan S, Wong J . Clinical implications of circulating angiogenic factors in cancer patients. J Clin Oncol. 2001; 19(4):1207-25. DOI: 10.1200/JCO.2001.19.4.1207. View

Erez N, Glanz S, Raz Y, Avivi C, Barshack I . Cancer associated fibroblasts express pro-inflammatory factors in human breast and ovarian tumors. Biochem Biophys Res Commun. 2013; 437(3):397-402. DOI: 10.1016/j.bbrc.2013.06.089. View

Kalluri R . The biology and function of fibroblasts in cancer. Nat Rev Cancer. 2016; 16(9):582-98. DOI: 10.1038/nrc.2016.73. View

Peng C, Tian Q, Yang G, Fang M, Zhang Z, Peng J . Quantum-dots based simultaneous detection of multiple biomarkers of tumor stromal features to predict clinical outcomes in gastric cancer. Biomaterials. 2012; 33(23):5742-52. DOI: 10.1016/j.biomaterials.2012.04.034. View

Tang D, Gao J, Wang S, Ye N, Chong Y, Huang Y . Cancer-associated fibroblasts promote angiogenesis in gastric cancer through galectin-1 expression. Tumour Biol. 2015; 37(2):1889-99. DOI: 10.1007/s13277-015-3942-9. View

Weber F, Byrne S, Le S, Brown D, Breit S, Scolyer R . Transforming growth factor-beta1 immobilises dendritic cells within skin tumours and facilitates tumour escape from the immune system. Cancer Immunol Immunother. 2005; 54(9):898-906. PMC: 11033026. DOI: 10.1007/s00262-004-0652-3. View

Weidner N, Carroll P, Flax J, BLUMENFELD W, Folkman J . Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am J Pathol. 1993; 143(2):401-9. PMC: 1887042. View

Suzuki H, Katsura A, Matsuyama H, Miyazono K . MicroRNA regulons in tumor microenvironment. Oncogene. 2014; 34(24):3085-94. PMC: 4761641. DOI: 10.1038/onc.2014.254. View

10.

Polanska U, Orimo A . Carcinoma-associated fibroblasts: non-neoplastic tumour-promoting mesenchymal cells. J Cell Physiol. 2013; 228(8):1651-7. DOI: 10.1002/jcp.24347. View

11.

Song Y, Ting Zhu Y, Ding J, Zhou F, Xue J, Jung J . Distribution of fibroblast growth factors and their roles in skin fibroblast cell migration. Mol Med Rep. 2016; 14(4):3336-42. DOI: 10.3892/mmr.2016.5646. View

12.

Yang J, Lu Y, Lin Y, Zheng Z, Fang J, He S . Vascular mimicry formation is promoted by paracrine TGF-β and SDF1 of cancer-associated fibroblasts and inhibited by miR-101 in hepatocellular carcinoma. Cancer Lett. 2016; 383(1):18-27. DOI: 10.1016/j.canlet.2016.09.012. View

13.

Pinedo H, Verheul H, DAmato R, Folkman J . Involvement of platelets in tumour angiogenesis?. Lancet. 1998; 352(9142):1775-7. DOI: 10.1016/s0140-6736(98)05095-8. View

14.

Rolny C, Mazzone M, Tugues S, Laoui D, Johansson I, Coulon C . HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF. Cancer Cell. 2011; 19(1):31-44. DOI: 10.1016/j.ccr.2010.11.009. View

15.

Augsten M, Hagglof C, Olsson E, Stolz C, Tsagozis P, Levchenko T . CXCL14 is an autocrine growth factor for fibroblasts and acts as a multi-modal stimulator of prostate tumor growth. Proc Natl Acad Sci U S A. 2009; 106(9):3414-9. PMC: 2651265. DOI: 10.1073/pnas.0813144106. View

16.

Mantovani A . La mala educación of tumor-associated macrophages: Diverse pathways and new players. Cancer Cell. 2010; 17(2):111-2. DOI: 10.1016/j.ccr.2010.01.019. View

17.

Wada J, Suzuki H, Fuchino R, Yamasaki A, Nagai S, Yanai K . The contribution of vascular endothelial growth factor to the induction of regulatory T-cells in malignant effusions. Anticancer Res. 2009; 29(3):881-8. View

18.

Yu B, Chen X, Li J, Qu Y, Su L, Peng Y . Stromal fibroblasts in the microenvironment of gastric carcinomas promote tumor metastasis via upregulating TAGLN expression. BMC Cell Biol. 2013; 14:17. PMC: 3610155. DOI: 10.1186/1471-2121-14-17. View

19.

Herrera M, Herrera A, Dominguez G, Silva J, Garcia V, Garcia J . Cancer-associated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patients. Cancer Sci. 2013; 104(4):437-44. PMC: 7657228. DOI: 10.1111/cas.12096. View

20.

Quante M, Tu S, Tomita H, Gonda T, Wang S, Takashi S . Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth. Cancer Cell. 2011; 19(2):257-72. PMC: 3060401. DOI: 10.1016/j.ccr.2011.01.020. View