Hormone Treatment of Meningiomas: Lack of Response to Medroxyprogesterone Acetate (MPA). A Pilot Study of Five Cases

Overview

Journal Acta Neurochir (Wien)

Specialty Neurosurgery

Date 1986 Jan 1

PMID 2939693

Citations 10

Authors

J Jaaskelainen

E Laasonen

J Karkkainen

M Haltia

H Troupp

Affiliations

Soon will be listed here.

Abstract

Medroxyprogesterone acetate (MPA) has been used in high doses as hormone treatment for metastatic breast cancer. We treated five intracranial meningiomas with MPA expecting that MPA would reduce the volume or decrease the growth rate. All five patients were postmenopausal women, aged 47 to 73 years. Before treatment, the growth rate of each tumour was assessed by two consecutive CT scans (CT 1 and CT 2). Tumours 1 to 4, histologically benign meningiomas, grew slowly as the tumour volumes were not found to increase in 21 to 45 months between CT 1 and CT 2. Tumour 5 was an anaplastic meningioma the rapid growth of which was evident in 8 weeks between CT 1 and CT 2. After CT 2, MPA was given 1,000 mg intramusculary once weekly for 17 to 29 weeks until CT 3 which showed the response. Tumours 1 to 4 had neither reduced in volume nor developed necroses, and tumour 5 continued its fast growth at the same rate as before.

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References

Donnell M, Meyer G, DONEGAN W . Estrogen-receptor protein in intracranial meningiomas. J Neurosurg. 1979; 50(4):499-502. DOI: 10.3171/jns.1979.50.4.0499. View

Markwalder T, Zava D, Goldhirsch A, Markwalder R . Estrogen and progesterone receptors in meningiomas in relation to clinical and pathologic features. Surg Neurol. 1983; 20(1):42-7. DOI: 10.1016/0090-3019(83)90104-0. View

STEEL G, LAMERTON L . The growth rate of human tumours. Br J Cancer. 1966; 20(1):74-86. PMC: 2008056. DOI: 10.1038/bjc.1966.9. View

PERTUISET B, Farah S, Clayes L, GOUTORBE J, Metzger J, Kujas M . Operability of intracranial meningiomas. Personal series of 353 cases. Acta Neurochir (Wien). 1985; 76(1-2):2-11. DOI: 10.1007/BF01403822. View

Jellinger K, SLOWIK F . Histological subtypes and prognostic problems in meningiomas. J Neurol. 1975; 208(4):279-98. DOI: 10.1007/BF00312803. View

Carella R, Ransohoff J, NEWALL J . Role of radiation therapy in the management of meningioma. Neurosurgery. 1982; 10(3):332-9. DOI: 10.1227/00006123-198203000-00006. View

Dethlefsen L, Prewitt J, Mendelsohn M . Analysis of tumor growth curves. J Natl Cancer Inst. 1968; 40(2):389-405. DOI: 10.1093/jnci/40.2.389. View

Yamashita T, Kuwabara T . Estimation of rate of growth of malignant brain tumors by computed tomography scanning. Surg Neurol. 1983; 20(6):464-70. DOI: 10.1016/0090-3019(83)90029-0. View

Simpson D . The recurrence of intracranial meningiomas after surgical treatment. J Neurol Neurosurg Psychiatry. 1957; 20(1):22-39. PMC: 497230. DOI: 10.1136/jnnp.20.1.22. View

10.

Horwitz K, Koseki Y, McGuire W . Estrogen control of progesterone receptor in human breast cancer: role of estradiol and antiestrogen. Endocrinology. 1978; 103(5):1742-51. DOI: 10.1210/endo-103-5-1742. View

11.

Meyer J . Growth and cell kinetic measurements in human tumors. Pathol Annu. 1981; 16(Pt 2):53-81. View

12.

Breiman R, Beck J, Korobkin M, Glenny R, Akwari O, Heaston D . Volume determinations using computed tomography. AJR Am J Roentgenol. 1982; 138(2):329-33. DOI: 10.2214/ajr.138.2.329. View

13.

Schwartz M, Randolph R, Cech D, Rose J, Panko W . Steroid hormone binding macromolecules in meningiomas. Failure to meet criteria of specific receptors. Cancer. 1984; 53(4):922-7. DOI: 10.1002/1097-0142(19840215)53:4<922::aid-cncr2820530418>3.0.co;2-i. View

14.

Vihko R, Janne O, Kontula K, Syrjala P . Female sex steroid receptor status in primary and metastatic breast carcinoma and its relationship to serum steroid peptide hormone levels. Int J Cancer. 1980; 26(1):13-21. DOI: 10.1002/ijc.2910260104. View

15.

Inoue H, Tamura M, Koizumi H, Nakamura M, Naganuma H, Ohye C . Clinical pathology of malignant meningiomas. Acta Neurochir (Wien). 1984; 73(3-4):179-91. DOI: 10.1007/BF01400851. View

16.

Glick R, Molteni A, Fors E . Hormone binding in brain tumors. Neurosurgery. 1983; 13(5):513-9. DOI: 10.1227/00006123-198311000-00005. View

17.

Pannuti F, Martoni A, Di Marco A, Piana E, Saccani F, Becchi G . Prospective, randomized clinical trial of two different high dosages of medroxyprogesterone acetate (MAP) in the treatment of metastatic breast cancer. Eur J Cancer (1965). 1979; 15(4):593-601. DOI: 10.1016/0014-2964(79)90097-5. View

18.

Cahill D, Bashirelahi N, Solomon L, Dalton T, Salcman M, Ducker T . Estrogen and progesterone receptors in meningiomas. J Neurosurg. 1984; 60(5):985-93. DOI: 10.3171/jns.1984.60.5.0985. View

19.

Yamashita J, Handa H, Iwaki K, Abe M . Recurrence of intracranial meningiomas, with special reference to radiotherapy. Surg Neurol. 1980; 14(1):33-40. View

20.

Yu Z, Wrange O, Haglund B, Granholm L, Gustafsson J . Estrogen and progestin receptors in intracranial meningiomas. J Steroid Biochem. 1982; 16(3):451-6. DOI: 10.1016/0022-4731(82)90059-0. View