Novel Insights into NDP52 Autophagy Receptor Functioning

Overview

Journal Trends Cell Biol

Specialty Cell Biology

Date 2018 Feb 4

PMID 29395717

Citations 16

Authors

Christophe Viret

Aurore Rozieres

Mathias Faure

Affiliations

Soon will be listed here.

Abstract

NDP52/CALCOCO2 makes multiple contributions to selective autophagy. By interacting with cargos and LC3, NDP52 directs autophagy targets to autophagosomes. In addition, NDP52 promotes autophagosomes fusion with endolysosomes by connecting autophagosomes to MYOSIN VI. Recent studies reveal that Rab35 GTPase controls NDP52 recruitment to its targets and that NDP52 triggers MYOSIN VI (MYO6) motility.

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