COL1A1 Promotes Metastasis in Colorectal Cancer by Regulating the WNT/PCP Pathway

Overview

Journal Mol Med Rep

Specialty Molecular Biology

Date 2018 Feb 3

PMID 29393423

Citations 78

Authors

Zheying Zhang

Yongxia Wang

Jinghang Zhang

Jiateng Zhong

Rui Yang

Affiliations

Soon will be listed here.

Abstract

Colorectal cancer (CRC) is the third leading cause of cancer‑associated mortality, and is a major health problem. Collagen type I α 1 (COL1A1) is a major component of collagen type I. Recently, it was reported to be overexpressed in a variety of tumor tissues and cells. However, the function of COL1A1 in CRC remains unclear. Herein, the present study demonstrated that COL1A1 was upregulated in CRC tissues and the paired lymph node tissues. Transwell assays showed that COL1A1 promoted CRC cell migration in vitro. Moreover, it was revealed that COL1A1 levels were correlated with those of WNT/planar cell polarity (PCP) signaling pathway genes; inhibition of COL1A1 decreased the expression levels of Ras‑related C3 botulinum toxin substrate 1‑GTP, phosphorylated‑c‑Jun N‑terminal kinase, and RhoA‑GTP, all of which are key genes in the WNT/PCP signaling pathway. These results may indicate the mechanisms underlying the oncogenic role of COL1A1 in CRC. In summary, the present data indicated that COL1A1 may serve as an oncoprotein, and that it may be used as a potential therapeutic target in CRC.

Citing Articles

PTTM: dissecting the profile of tumor tissue microbiome to reveal microbiota features and associations with host transcriptome.

Yao R, Sun L, Gao R, Mei Y, Xue G, Yu D Brief Bioinform. 2025; 26(1).

PMID: 39924716 PMC: 11807729. DOI: 10.1093/bib/bbaf057.

Col1A1 as a new decoder of clinical features and immune microenvironment in ovarian cancer.

Xiao X, Long F, Yu S, Wu W, Nie D, Ren X Front Immunol. 2025; 15():1496090.

PMID: 39845977 PMC: 11750837. DOI: 10.3389/fimmu.2024.1496090.

Discovery of prognostic lncRNAs in colorectal cancer using spatial transcriptomics.

Pinkney H, Ross C, Hodgson T, Pattison S, Diermeier S NPJ Precis Oncol. 2024; 8(1):230.

PMID: 39390212 PMC: 11467462. DOI: 10.1038/s41698-024-00728-1.

Integrative analysis regarding the correlation between collagen-related genes and prostate cancer.

Xiao Y, Lai C, Hu J, Mulati Y, Xu X, Luo J BMC Cancer. 2024; 24(1):1038.

PMID: 39174928 PMC: 11342612. DOI: 10.1186/s12885-024-12783-9.

The Spatial Extracellular Proteomic Tumor Microenvironment Distinguishes Molecular Subtypes of Hepatocellular Carcinoma.

Macdonald J, Taylor H, Wang M, DelaCourt A, Edge C, Lewin D J Proteome Res. 2024; 23(9):3791-3805.

PMID: 38980715 PMC: 11385377. DOI: 10.1021/acs.jproteome.4c00099.

References

Willis C, Kluppel M . Chondroitin sulfate-E is a negative regulator of a pro-tumorigenic Wnt/beta-catenin-Collagen 1 axis in breast cancer cells. PLoS One. 2014; 9(8):e103966. PMC: 4121171. DOI: 10.1371/journal.pone.0103966. View

Subramanian A, Tamayo P, Mootha V, Mukherjee S, Ebert B, Gillette M . Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005; 102(43):15545-50. PMC: 1239896. DOI: 10.1073/pnas.0506580102. View

Yuan L, Zhou C, Lu Y, Hong M, Zhang Z, Zhang Z . IFN-γ-mediated IRF1/miR-29b feedback loop suppresses colorectal cancer cell growth and metastasis by repressing IGF1. Cancer Lett. 2015; 359(1):136-47. DOI: 10.1016/j.canlet.2015.01.003. View

Zou X, Feng B, Dong T, Yan G, Tan B, Shen H . Up-regulation of type I collagen during tumorigenesis of colorectal cancer revealed by quantitative proteomic analysis. J Proteomics. 2013; 94:473-85. DOI: 10.1016/j.jprot.2013.10.020. View

Livak K, Schmittgen T . Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2002; 25(4):402-8. DOI: 10.1006/meth.2001.1262. View

Zeke A, Misheva M, Remenyi A, Bogoyevitch M . JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships. Microbiol Mol Biol Rev. 2016; 80(3):793-835. PMC: 4981676. DOI: 10.1128/MMBR.00043-14. View

Siegel R, Miller K, Jemal A . Cancer Statistics, 2017. CA Cancer J Clin. 2017; 67(1):7-30. DOI: 10.3322/caac.21387. View

Zhang H, Liu B, Xu X, Jiang T, Zhang X, Shi Y . Pathophysiology of chronic pancreatitis induced by dibutyltin dichloride joint ethanol in mice. World J Gastroenterol. 2016; 22(10):2960-70. PMC: 4779919. DOI: 10.3748/wjg.v22.i10.2960. View

Gu Y, Wang Q, Guo K, Qin W, Liao W, Wang S . TUSC3 promotes colorectal cancer progression and epithelial-mesenchymal transition (EMT) through WNT/β-catenin and MAPK signalling. J Pathol. 2016; 239(1):60-71. DOI: 10.1002/path.4697. View

10.

Brooks M, Mo Q, Krasnow R, Ho P, Lee Y, Xiao J . Positive association of collagen type I with non-muscle invasive bladder cancer progression. Oncotarget. 2016; 7(50):82609-82619. PMC: 5347718. DOI: 10.18632/oncotarget.12089. View

11.

Tian Z, Li Z, Wen S, Zhang Y, Li Y, Cheng J . Identification of Commonly Dysregulated Genes in Non-small-cell Lung Cancer by Integrated Analysis of Microarray Data and qRT-PCR Validation. Lung. 2015; 193(4):583-92. DOI: 10.1007/s00408-015-9726-6. View

12.

Hurst R, Elliott R, Goldson A, Fairweather-Tait S . Se-methylselenocysteine alters collagen gene and protein expression in human prostate cells. Cancer Lett. 2008; 269(1):117-26. DOI: 10.1016/j.canlet.2008.04.025. View

13.

Yu P, Yan M, Lai H, Huang R, Chou Y, Lin W . Downregulation of miR-29 contributes to cisplatin resistance of ovarian cancer cells. Int J Cancer. 2013; 134(3):542-51. DOI: 10.1002/ijc.28399. View

14.

Mootha V, Lindgren C, Eriksson K, Subramanian A, Sihag S, Lehar J . PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet. 2003; 34(3):267-73. DOI: 10.1038/ng1180. View

15.

Poplawski P, Rybicka B, Boguslawska J, Rodzik K, Visser T, Nauman A . Induction of type 1 iodothyronine deiodinase expression inhibits proliferation and migration of renal cancer cells. Mol Cell Endocrinol. 2016; 442:58-67. DOI: 10.1016/j.mce.2016.12.004. View

16.

Monin M, Krause P, Stelling R, Bocuk D, Niebert S, Klemm F . The anthelmintic niclosamide inhibits colorectal cancer cell lines via modulation of the canonical and noncanonical Wnt signaling pathway. J Surg Res. 2016; 203(1):193-205. DOI: 10.1016/j.jss.2016.03.051. View

17.

Zhang Y, Lin L, Jin Y, Lin Y, Cao Y, Zheng C . Overexpression of WNT5B promotes COLO 205 cell migration and invasion through the JNK signaling pathway. Oncol Rep. 2016; 36(1):23-30. DOI: 10.3892/or.2016.4772. View

18.

Maasalu K, Nikopensius T, Koks S, Noukas M, Kals M, Prans E . Whole-exome sequencing identifies de novo mutation in the COL1A1 gene to underlie the severe osteogenesis imperfecta. Hum Genomics. 2015; 9:6. PMC: 4429824. DOI: 10.1186/s40246-015-0028-0. View

19.

Li J, Ding Y, Li A . Identification of COL1A1 and COL1A2 as candidate prognostic factors in gastric cancer. World J Surg Oncol. 2016; 14(1):297. PMC: 5126984. DOI: 10.1186/s12957-016-1056-5. View

20.

Tang Z, Li C, Kang B, Gao G, Li C, Zhang Z . GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017; 45(W1):W98-W102. PMC: 5570223. DOI: 10.1093/nar/gkx247. View