Role of Fine-Needle Aspiration Biopsy in the Management of Salivary Gland Masses

Overview

Journal Turk Arch Otorhinolaryngol

Publisher Galenos Publishing House

Specialty Otorhinolaryngology

Date 2018 Feb 3

PMID 29392028

Citations 8

Authors

Deniz Tuna Edizer

Ela Araz Server

Ozgur Yigit

Muhammet Yildiz

Affiliations

Soon will be listed here.

Abstract

Objective: Fine-needle aspiration biopsy (FNAB) is widely used in the management of salivary gland masses. Its main advantage is its ability to differentiate benign from malignant disease. In this study, we aimed to evaluate the diagnostic ability of FNAB in salivary gland masses.

Methods: The records of patients who had undergone FNAB before parotidectomy or submandibular gland excision between 2005 and 2013 were retrospectively analyzed. FNAB results were classified as negative, positive, suspicious for malignancy, and non-diagnostic. Preoperative FNAB results were compared with definitive histopathological results. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of FNAB results were calculated.

Results: A total of 285 patients were enrolled. Among them, 230 (80.7%) had parotid gland and 55 (19.3%) had submandibular gland masses. Following a definitive histopathological examination, the most common benign tumor was pleomorphic adenoma (52.6%), whereas malignant tumors were mucoepidermoid carcinoma (2%) and squamous cell carcinoma (2%). The sensitivity, specificity, PPV, NPV and accuracy of FNAB results were 76.9%, 95.4%, 75%, 95.9%, and 92.6%, respectively. The rate of a suspicious cytology was 5.2% (15 patients) and that of a non-diagnostic cytology was 8.8% (25 patients).

Conclusion: FNAB is a safe and simple diagnostic tool for the diagnosis of salivary gland masses and has a relatively high sensitivity and specificity. It may provide valuable information for patient counselling and surgical planning. The major drawbacks include a lower sensitivity than specificity and a relatively high rate of non-diagnostic results.

Citing Articles

Clinical Behavior and Molecular Insights of Secretory Carcinoma of Salivary Glands, a Single Center Experience.

Bassani S, Fiorini D, Destefanis M, Arsie A, Mulone D, Eccher A Indian J Otolaryngol Head Neck Surg. 2024; 76(5):4153-4162.

PMID: 39376339 PMC: 11455849. DOI: 10.1007/s12070-024-04807-4.

Utility of fine-needle aspiration biopsy (FNAB) in parotid pleomorphic adenoma diagnosis and management.

Fikova A, Novak S, Kalfert D, Kuchar M, Zabrodsky M, Dostalova L Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023; 168(2):156-161.

PMID: 37431621 DOI: 10.5507/bp.2023.027.

Cytologic diagnosis of parotid gland Warthin tumor: Systematic review and meta-analysis.

Fisher R, Ronen O Head Neck. 2022; 44(10):2277-2287.

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Ultrasound-guided core biopsy in the diagnosis of parotid neoplasia: an overview and update with a review of the literature.

Hurry K, Karunaratne D, Westley S, Booth A, Ramesar K, Zhang T Br J Radiol. 2021; 95(1130):20210972.

PMID: 34860569 PMC: 8822560. DOI: 10.1259/bjr.20210972.

An Overview on the Histogenesis and Morphogenesis of Salivary Gland Neoplasms and Evolving Diagnostic Approaches.

Iyer J, Hariharan A, Cao U, Mai C, Wang A, Khayambashi P Cancers (Basel). 2021; 13(15).

PMID: 34359811 PMC: 8345412. DOI: 10.3390/cancers13153910.

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