Antimalarial Activity of the Solvent Fractions of Fruit Rind and Root of Linn (Caricaceae) Against in Mice

Overview

Journal J Parasitol Res

Publisher Wiley

Specialty Parasitology

Date 2018 Feb 3

PMID 29391947

Citations 14

Authors

Gemechu Zeleke

Dereje Kebebe

Eshetu Mulisa

Fanta Gashe

Affiliations

Soon will be listed here.

Abstract

Background: Currently, antimalarial drug resistance poses a serious challenge. This stresses the need for newer antimalarial compounds. is used traditionally and showed antimalarial activity. This study attempted to evaluate antimalarial activity of in mice.

Methods: antimalarial activity of solvent fractions of the plant was carried out against early infection in mice. Parasitemia, temperature, PCV, and body weight of mice were recorded. Windows SPSS version 16 (one-way ANOVA followed by Tukey's post hoc test) was used for data analysis.

Results: The pet ether and chloroform fractions of fruit rind and root produced a significant ( < 0.001) chemosuppressive effect. A maximum parasite suppression of 61.78% was produced by pet ether fraction of fruit rind in the highest dose (400 mg/kg/day). Only 400 mg/kg/day dose of chloroform fraction of root exhibited a parasite suppression effect (48.11%). But, methanol fraction of the plant parts produced less chemosuppressive effect.

Conclusion: Pet ether fraction of fruit rind had the highest antimalarial activity and could be a potential source of lead compound. Further study should be done to show the chemical and metabolomic profile of active ingredients.

Citing Articles

Anti-malarial and haematological evaluation of the ethanolic, ethyl acetate and aqueous fractions of Chromolaena odorata.

Elebiyo T, Oluba O, Adeyemi O BMC Complement Med Ther. 2023; 23(1):402.

PMID: 37946127 PMC: 10634035. DOI: 10.1186/s12906-023-04200-8.

Potential Plant-Based New Antiplasmodial Agent Used in Papua Island, Indonesia.

Indradi R, Muhaimin M, Barliana M, Khatib A Plants (Basel). 2023; 12(9).

PMID: 37176870 PMC: 10181418. DOI: 10.3390/plants12091813.

Medicinal plants used in traditional treatment of malaria in Ethiopia: a review of ethnomedicine, anti-malarial and toxicity studies.

Nigussie G, Wale M Malar J. 2022; 21(1):262.

PMID: 36088324 PMC: 9463824. DOI: 10.1186/s12936-022-04264-w.

Antimalarial activity of solvent fractions of a leaf of Eucalyptus globulus labill against Plasmodium berghei infected mice.

Ayalew M, Atnafie S, Bekele A BMC Complement Med Ther. 2022; 22(1):221.

PMID: 35974350 PMC: 9380366. DOI: 10.1186/s12906-022-03702-1.

In vivo antiplasmodial activities and acute toxicity assessment of two plant cocktail extracts commonly used among Southwestern Nigerians.

Omagha R, Idowu E, Alimba C, Otubanjo O, Oyibo W, Agbaje E J Parasit Dis. 2022; 46(2):343-353.

PMID: 35692481 PMC: 9177911. DOI: 10.1007/s12639-021-01450-6.

References

Bhagavathula A, Elnour A, Shehab A . Alternatives to currently used antimalarial drugs: in search of a magic bullet. Infect Dis Poverty. 2016; 5(1):103. PMC: 5095999. DOI: 10.1186/s40249-016-0196-8. View

Menard D, Dondorp A . Antimalarial Drug Resistance: A Threat to Malaria Elimination. Cold Spring Harb Perspect Med. 2017; 7(7). PMC: 5495053. DOI: 10.1101/cshperspect.a025619. View

Munoz V, Sauvain M, Bourdy G, Callapa J, Bergeron S, Rojas I . A search for natural bioactive compounds in Bolivia through a multidisciplinary approach. Part I. Evaluation of the antimalarial activity of plants used by the Chacobo Indians. J Ethnopharmacol. 2000; 69(2):127-37. DOI: 10.1016/s0378-8741(99)00148-8. View

Chinchilla M, Guerrero O, Abarca G, Barrios M, Castro O . An in vivo model to study the anti-malaric capacity of plant extracts. Rev Biol Trop. 1998; 46(1):35-9. View

Frederich M, Tits M, Angenot L . Potential antimalarial activity of indole alkaloids. Trans R Soc Trop Med Hyg. 2007; 102(1):11-9. DOI: 10.1016/j.trstmh.2007.10.002. View

Sougoufara S, Doucoure S, Backe Sembene P, Harry M, Sokhna C . Challenges for malaria vector control in sub-Saharan Africa: Resistance and behavioral adaptations in populations. J Vector Borne Dis. 2017; 54(1):4-15. View

Ashley E, Dhorda M, Fairhurst R, Amaratunga C, Lim P, Suon S . Spread of artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med. 2014; 371(5):411-23. PMC: 4143591. DOI: 10.1056/NEJMoa1314981. View

Otsuki N, Dang N, Kumagai E, Kondo A, Iwata S, Morimoto C . Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects. J Ethnopharmacol. 2009; 127(3):760-7. DOI: 10.1016/j.jep.2009.11.024. View

Bhat G, Surolia N . In vitro antimalarial activity of extracts of three plants used in the traditional medicine of India. Am J Trop Med Hyg. 2001; 65(4):304-8. DOI: 10.4269/ajtmh.2001.65.304. View

10.

Bero J, Frederich M, Quetin-Leclercq J . Antimalarial compounds isolated from plants used in traditional medicine. J Pharm Pharmacol. 2009; 61(11):1401-33. DOI: 10.1211/jpp/61.11.0001. View

11.

Ntie-Kang F, Amoa Onguene P, Lifongo L, Ndom J, Sippl W, Mbaze L . The potential of anti-malarial compounds derived from African medicinal plants, part II: a pharmacological evaluation of non-alkaloids and non-terpenoids. Malar J. 2014; 13:81. PMC: 3975711. DOI: 10.1186/1475-2875-13-81. View

12.

Fidock D, Rosenthal P, Croft S, Brun R, Nwaka S . Antimalarial drug discovery: efficacy models for compound screening. Nat Rev Drug Discov. 2004; 3(6):509-20. DOI: 10.1038/nrd1416. View

13.

Deharo E, Bourdy G, Quenevo C, Munoz V, Ruiz G, Sauvain M . A search for natural bioactive compounds in Bolivia through a multidisciplinary approach. Part V. Evaluation of the antimalarial activity of plants used by the Tacana Indians. J Ethnopharmacol. 2001; 77(1):91-8. DOI: 10.1016/s0378-8741(01)00270-7. View

14.

Falade M, Akinboye D, Gbotosho G, Ajaiyeoba E, Happi T, Abiodun O . In Vitro and In Vivo Antimalarial Activity of Ficus thonningii Blume (Moraceae) and Lophira alata Banks (Ochnaceae), Identified from the Ethnomedicine of the Nigerian Middle Belt. J Parasitol Res. 2014; 2014:972853. PMC: 4052051. DOI: 10.1155/2014/972853. View

15.

Inbaneson S, Ravikumar S, Suganthi P . In vitro antiplasmodial effect of ethanolic extracts of coastal medicinal plants along Palk Strait against Plasmodium falciparum. Asian Pac J Trop Biomed. 2013; 2(5):364-7. PMC: 3609306. DOI: 10.1016/S2221-1691(12)60057-4. View

16.

Schmidt T, Khalid S, Romanha A, Alves T, Biavatti M, Brun R . The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - part II. Curr Med Chem. 2012; 19(14):2176-228. View

17.

Mahajan S, Kamath V, Ghatpande S . Synergistic antimalarial activity of ketones with rufigallol and vitamin C. Parasitology. 2005; 131(Pt 4):459-66. DOI: 10.1017/S0031182005008267. View

18.

Imwong M, Suwannasin K, Kunasol C, Sutawong K, Mayxay M, Rekol H . The spread of artemisinin-resistant Plasmodium falciparum in the Greater Mekong subregion: a molecular epidemiology observational study. Lancet Infect Dis. 2017; 17(5):491-497. PMC: 5406483. DOI: 10.1016/S1473-3099(17)30048-8. View

19.

Amelo W, Nagpal P, Makonnen E . Antiplasmodial activity of solvent fractions of methanolic root extract of Dodonaea angustifolia in Plasmodium berghei infected mice. BMC Complement Altern Med. 2014; 14:462. PMC: 4289057. DOI: 10.1186/1472-6882-14-462. View