The Relationship of Alanine Aminotransferase to Metabolic Syndrome in a Korean Population

Overview

Journal Turk J Gastroenterol

Publisher Aves

Specialty Gastroenterology

Date 2018 Feb 3

PMID 29391308

Citations 4

Authors

Seok Hoon Lee

Doo Yeoun Cho

Nam Seok Joo

Kwang Min Kim

Kyu Nam Kim

Affiliations

Soon will be listed here.

Abstract

Background/aims: Although associations between serum alanine aminotransferase and metabolic syndrome are well-recognized in Western countries, only a limited number of prospective studies have been performed in Asian populations. The aim of the study was to cross-sectionally and longitudinally examine whether serum alanine aminotransferase levels are associated with metabolic syndrome and its associated components in a Korean population.

Materials And Methods: A total of 31,832 subjects who received health screenings were included in cross-sectional analyses; a subgroup of 4.070 subjects without metabolic syndrome at baseline was included in the longitudinal analyses. The metabolic syndrome definition was based on the National Cholesterol Education Program Third Adult Treatment Panel criteria with modification on waist circumference cut-off to be more appropriate for an Asian population.

Results: In the cross-sectional analyses, serum alanine aminotransferase is positively associated with metabolic syndrome and its components. In the longitudinal analyses, the prevalence of metabolic syndrome increased across serum alanine aminotransferase quartiles in a dose-dependent manner after extensive adjustments (hazard ratios were 1.000, 1.609, 2.601, and 3.015 for quartiles, 1 through quartile 4; P for trend<0.001).

Conclusion: Our study confirmed a positive association between components of metabolic syndrome and elevated serum alanine aminotransferase in a Korean population.

Citing Articles

Morbid liver manifestations are intrinsically bound to metabolic syndrome and nutrient intake based on a machine-learning cluster analysis.

Mico V, San-Cristobal R, Martin R, Martinez-Gonzalez M, Salas-Salvado J, Corella D Front Endocrinol (Lausanne). 2022; 13:936956.

PMID: 36147576 PMC: 9487178. DOI: 10.3389/fendo.2022.936956.

The Association between Metabolic Syndrome and Elevated Alanine Aminotransferase Levels in an Indigenous Population in Northern Taiwan: A Community-Based and Cross-Sectional Study.

Chen Y, Lin Y, Yeh W, Tsao Y, Li W, Fang W Evid Based Complement Alternat Med. 2021; 2020:6612447.

PMID: 33488746 PMC: 7787776. DOI: 10.1155/2020/6612447.

Association of total bilirubin and indirect bilirubin content with metabolic syndrome among Kazakhs in Xinjiang.

Hao H, Guo H, Ma R, Yan Y, Hu Y, Ma J BMC Endocr Disord. 2020; 20(1):110.

PMID: 32698889 PMC: 7376964. DOI: 10.1186/s12902-020-00563-y.

Measurement of the Combined Levels of Serum Uric Acid and Alanine Aminotransferase and the Risk of Metabolic Syndrome in a Population Aged 60 Years or More in Northeastern China.

Wang J, Wang Y, Chen F, Ma G, Wang D Med Sci Monit. 2020; 26:e916459.

PMID: 31958336 PMC: 6990664. DOI: 10.12659/MSM.916459.

References

Pratt D, KAPLAN M . Evaluation of abnormal liver-enzyme results in asymptomatic patients. N Engl J Med. 2000; 342(17):1266-71. DOI: 10.1056/NEJM200004273421707. View

Greenfield T . Ways of measuring drinking patterns and the difference they make: experience with graduated frequencies. J Subst Abuse. 2001; 12(1-2):33-49. DOI: 10.1016/s0899-3289(00)00039-0. View

. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. 2001; 285(19):2486-97. DOI: 10.1001/jama.285.19.2486. View

Garg A, Misra A . Hepatic steatosis, insulin resistance, and adipose tissue disorders. J Clin Endocrinol Metab. 2002; 87(7):3019-22. DOI: 10.1210/jcem.87.7.8736. View

Seppala-Lindroos A, Vehkavaara S, Hakkinen A, Goto T, Westerbacka J, Sovijarvi A . Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab. 2002; 87(7):3023-8. DOI: 10.1210/jcem.87.7.8638. View

Lee D, Jacobs Jr D, Gross M, Kiefe C, Roseman J, Lewis C . Gamma-glutamyltransferase is a predictor of incident diabetes and hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Clin Chem. 2003; 49(8):1358-66. DOI: 10.1373/49.8.1358. View

Lorenzo C, Okoloise M, Williams K, Stern M, Haffner S . The metabolic syndrome as predictor of type 2 diabetes: the San Antonio heart study. Diabetes Care. 2003; 26(11):3153-9. DOI: 10.2337/diacare.26.11.3153. View

Chen J, Muntner P, Hamm L, Jones D, Batuman V, Fonseca V . The metabolic syndrome and chronic kidney disease in U.S. adults. Ann Intern Med. 2004; 140(3):167-74. DOI: 10.7326/0003-4819-140-3-200402030-00007. View

Nakanishi N, Suzuki K, Tatara K . Serum gamma-glutamyltransferase and risk of metabolic syndrome and type 2 diabetes in middle-aged Japanese men. Diabetes Care. 2004; 27(6):1427-32. DOI: 10.2337/diacare.27.6.1427. View

10.

Westerbacka J, Corner A, Tiikkainen M, Tamminen M, Vehkavaara S, Hakkinen A . Women and men have similar amounts of liver and intra-abdominal fat, despite more subcutaneous fat in women: implications for sex differences in markers of cardiovascular risk. Diabetologia. 2004; 47(8):1360-9. DOI: 10.1007/s00125-004-1460-1. View

11.

Suzuki A, Angulo P, Lymp J, St Sauver J, Muto A, Okada T . Chronological development of elevated aminotransferases in a nonalcoholic population. Hepatology. 2005; 41(1):64-71. DOI: 10.1002/hep.20543. View

12.

Bugianesi E, Gastaldelli A, Vanni E, Gambino R, Cassader M, Baldi S . Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms. Diabetologia. 2005; 48(4):634-42. DOI: 10.1007/s00125-005-1682-x. View

13.

Eckel R, Grundy S, Zimmet P . The metabolic syndrome. Lancet. 2005; 365(9468):1415-28. DOI: 10.1016/S0140-6736(05)66378-7. View

14.

Alberti K, Zimmet P, Shaw J . The metabolic syndrome--a new worldwide definition. Lancet. 2005; 366(9491):1059-62. DOI: 10.1016/S0140-6736(05)67402-8. View

15.

Hanley A, Williams K, Festa A, Wagenknecht L, DAgostino Jr R, Haffner S . Liver markers and development of the metabolic syndrome: the insulin resistance atherosclerosis study. Diabetes. 2005; 54(11):3140-7. DOI: 10.2337/diabetes.54.11.3140. View

16.

Kim H, Choi K, Jang Y, Shin H, Kim D . Normal serum aminotransferase levels and the metabolic syndrome: Korean National Health and Nutrition Examination Surveys. Yonsei Med J. 2006; 47(4):542-50. PMC: 2687736. DOI: 10.3349/ymj.2006.47.4.542. View

17.

Schindhelm R, Dekker J, Nijpels G, Stehouwer C, Bouter L, Heine R . Alanine aminotransferase and the 6-year risk of the metabolic syndrome in Caucasian men and women: the Hoorn Study. Diabet Med. 2007; 24(4):430-5. DOI: 10.1111/j.1464-5491.2007.02100.x. View

18.

Goessling W, Massaro J, Vasan R, DAgostino Sr R, Ellison R, Fox C . Aminotransferase levels and 20-year risk of metabolic syndrome, diabetes, and cardiovascular disease. Gastroenterology. 2008; 135(6):1935-44, 1944.e1. PMC: 3039001. DOI: 10.1053/j.gastro.2008.09.018. View

19.

Yun K, Shin C, Yoon Y, Park H . Elevated alanine aminotransferase levels predict mortality from cardiovascular disease and diabetes in Koreans. Atherosclerosis. 2009; 205(2):533-7. DOI: 10.1016/j.atherosclerosis.2008.12.012. View

20.

Mottillo S, Filion K, Genest J, Joseph L, Pilote L, Poirier P . The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis. J Am Coll Cardiol. 2010; 56(14):1113-32. DOI: 10.1016/j.jacc.2010.05.034. View