Mycobacterium Tuberculosis Molecular Determinants of Infection, Survival Strategies, and Vulnerable Targets

Overview

Journal Pathogens

Date 2018 Feb 2

PMID 29389854

Citations 16

Authors

Davide M Ferraris

Riccardo Miggiano

Franca Rossi

Menico Rizzi

Affiliations

Soon will be listed here.

Abstract

is the causative agent of tuberculosis, an ancient disease which, still today, represents a major threat for the world population. Despite the advances in medicine and the development of effective antitubercular drugs, the cure of tuberculosis involves prolonged therapies which complicate the compliance and monitoring of drug administration and treatment. Moreover, the only available antitubercular vaccine fails to provide an effective shield against adult lung tuberculosis, which is the most prevalent form. Hence, there is a pressing need for effective antitubercular drugs and vaccines. This review highlights recent advances in the study of selected key molecular determinants of infection and vulnerable targets whose structures could be exploited for the development of new antitubercular agents.

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