Diverted Total Synthesis of the Baulamycins and Analogues Reveals an Alternate Mechanism of Action

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2018 Feb 2

PMID 29388431

Citations 4

Authors

Andrew D Steele

Guillaume Ernouf

Young Eun Lee

William M Wuest

Affiliations

Soon will be listed here.

Abstract

The baulamycins were identified as in vitro siderophore biosynthesis inhibitors. Diverted total synthesis was used to construct the natural products and eight strategic analogues, three of which had improved inhibitory activity. Biological testing then revealed that membrane damage is the predominant mode of action in Staphylococcus aureus cells.

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