Genome Sequence and Comparative Genomic Analysis of a Clinically Important Strain CD11-4 of Isolated from Celiac Disease Patient

Overview

Journal Gut Pathog

Publisher Biomed Central

Specialty Gastroenterology

Date 2018 Feb 2

PMID 29387173

Citations 6

Authors

Atul Munish Chander

Rakesh Kochhar

Devinder Kumar Dhawan

Sanjay Kumar Bhadada

Shanmugam Mayilraj

Affiliations

Soon will be listed here.

Abstract

Background: and other member of this genus are known to cause bacteremia and serious clinical comorbidities, but there is no study reporting about pathogenicity attributes of is known to cause lethal infection. Reporting the genome of CD11-4 and comparative genomics with other members of genus has provided some novel insights that can enable us to understand the mechanisms responsible for its pathogenicity in humans.

Results: Comparative genomic analysis by Rapid Annotation Server and Technology revealed the presence of similar virulence determinant genes in both NBRC 107853 and CD11-4. Like NBRC 107853, CD11-4 contained two genes responsible for resistance against β-lactam class of antibiotics and two genes for resistance against fluoroquinolones. Interestingly, CD11-4 contained a unique gene coding for multidrug resistance efflux pumps unlike all other members of this genus. It also contained two genes involved in Toxin-antitoxin Systems that were absent in NBRC 107853 but were present in some other members of genus.

Conclusions: Genome annotations of CD11-4 revealed that it contained similar or more virulence repertoire like NBRC 107853. Like other gut pathogens, possesses key virulence determinant genes for antibiotic resistance, invasion, adhesion, biofilm formation, iron acquisition and to cope with stress response, thereby indicating that strain CD11-4 could be a gut pathogen.

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