Insight into the Molecular Genetics of Myopia

Overview

Journal Mol Vis

Specialties Cell Biology
Molecular Biology
Ophthalmology

Date 2018 Feb 2

PMID 29386878

Citations 29

Authors

Jiali Li

Qingjiong Zhang

Affiliations

Soon will be listed here.

Abstract

Myopia is the most common cause of visual impairment worldwide. Genetic and environmental factors contribute to the development of myopia. Studies on the molecular genetics of myopia are well established and have implicated the important role of genetic factors. With linkage analysis, association studies, sequencing analysis, and experimental myopia studies, many of the loci and genes associated with myopia have been identified. Thus far, there has been no systemic review of the loci and genes related to non-syndromic and syndromic myopia based on the different approaches. Such a systemic review of the molecular genetics of myopia will provide clues to identify additional plausible genes for myopia and help us to understand the molecular mechanisms underlying myopia. This paper reviews recent genetic studies on myopia, summarizes all possible reported genes and loci related to myopia, and suggests implications for future studies on the molecular genetics of myopia.

Citing Articles

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A novel variant in the keratin 12 gene in a four-generation Chinese family with high myopia.

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Peripheral Eye Length Evaluation in Myopic Children Undergoing Orthokeratology Treatment for 12 Months Using MRI.

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Exploring the Research Landscape of High Myopia: Trends, Contributors, and Key Areas of Focus.

Chi K, Li B, Huang H, Sun J, Zheng Y, Zhao L Med Sci Monit. 2023; 29:e941670.

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