Visualization of Microaneurysms Using Optical Coherence Tomography Angiography: Comparison of OCTA En Face, OCT B-scan, OCT En Face, FA, and IA Images

Overview

Journal Jpn J Ophthalmol

Specialty Ophthalmology

Date 2018 Feb 1

PMID 29383540

Citations 20

Authors

Masafumi Hamada

Kishiko Ohkoshi

Keiji Inagaki

Nobuyuki Ebihara

Akira Murakami

Affiliations

Soon will be listed here.

Abstract

Purpose: To compare the visualization of microaneurysms (MAs) in patients with diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA) with that using fluorescein angiography (FA).

Study Design: Prospective, clinical, and experimental.

Methods: This study was a prospective evaluation of imaging technology. Thirty-seven eyes of 33 patients with DR were scanned using an OCTA instrument. The 83 MAs that were confirmed on OCT B-scan and OCT en face images were evaluated using OCTA, and these findings were compared with those evaluated using FA.

Results: Of the 83 MAs confirmed on OCT B-scan images, 73 (88%) were clearly visualized on the OCTA en face images as nodular or comma-shaped structures, while the remaining 12% did not present with a typical MA or vascular structure on the OCTA en face images at the relevant positions. Seventy-four of the 83 MAs (87%) confirmed on the OCT B-scan images presented as punctate hyperfluorescent spots on the FA images. On the FA images, 8 of 9 (88%) MAs absent on the OCTA en face images presented as hyperfluorescent spots. Visualization of the MAs on the OCTA en face images did not correlate with the OCT B-scan images of the MA lumens (open, closed, or heterogeneous).

Conclusions: For diabetic maculopathy, OCTA en face images do not present with comprehensive MAs images, indicating that some MAs might be overlooked with OCTA en face images.

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