Chronic Autoimmune Disorders Are Increased in Coeliac Disease: A Case-control Study

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2018 Feb 1

PMID 29381930

Citations 25

Authors

Stefano Bibbo

Giovanni Mario Pes

Paolo Usai-Satta

Roberta Salis

Sara Soro

Bianca Maria Quarta Colosso

Maria Pina Dore

Affiliations

Soon will be listed here.

Abstract

Coeliac disease (CD) is an autoimmune disorder of the small bowel associated with increased risk of additional autoimmune diseases (ADs).To investigate the prevalence of ADs in a population of adult coeliac patients.This was a retrospective case-control study. Data from coeliac patients and controls referred to a tertiary center between 2013 and 2016 were collected. The frequency of ADs and the unadjusted and adjusted odds ratios (ORs) for age, gender, disease duration, and body mass index with their 95% confidence intervals (CIs) were evaluated.Two hundred fifty-five patients with CD (median age 37.1 years; 206 women) were matched with 250 controls. ADs were more frequent (35.3%) in coeliac patients than in controls (15.2%). Adjusted ORs for the presence of only 1, at least 1, and more than 1 AD were 3.13 (95% CI 1.81-5.42, P < .0001), 3.31 (95% CI 2.00-5.46, P < .0001), and 3.93 (95% CI 1.49-10.36, P = .006), respectively. Hashimoto thyroiditis was the most prevalent AD (24.3% vs. 10%) OR = 2.55 (95% CI 1.39-4.70, P < .0001), followed by psoriasis (4.3% vs. 1.6%), type 1 diabetes (2.7% vs. 0.4%), and Sjögren syndrome (2.4% vs. 0.4%).These findings suggest a need for a careful surveillance of autoimmune status, especially for Hashimoto thyroiditis in patients with celiac disease.

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References

Ventura A, Magazzu G, Greco L . Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease. SIGEP Study Group for Autoimmune Disorders in Celiac Disease. Gastroenterology. 1999; 117(2):297-303. DOI: 10.1053/gast.1999.0029900297. View

Assa A, Frenkel-Nir Y, Tzur D, Katz L, Shamir R . Large population study shows that adolescents with celiac disease have an increased risk of multiple autoimmune and nonautoimmune comorbidities. Acta Paediatr. 2017; 106(6):967-972. DOI: 10.1111/apa.13808. View

Meloni G, Dore A, Fanciulli G, Tanda F, Bottazzo G . Subclinical coeliac disease in schoolchildren from northern Sardinia. Lancet. 1999; 353(9146):37. DOI: 10.1016/S0140-6736(05)74871-6. View

Houlston R, Tomlinson I, Ford D, Seal S, Marossy A, Ferguson A . Linkage analysis of candidate regions for coeliac disease genes. Hum Mol Genet. 1997; 6(8):1335-9. DOI: 10.1093/hmg/6.8.1335. View

Smyth D, Plagnol V, Walker N, Cooper J, Downes K, Yang J . Shared and distinct genetic variants in type 1 diabetes and celiac disease. N Engl J Med. 2008; 359(26):2767-77. PMC: 2840835. DOI: 10.1056/NEJMoa0807917. View

Byass P, Kahn K, Ivarsson A . The global burden of childhood coeliac disease: a neglected component of diarrhoeal mortality?. PLoS One. 2011; 6(7):e22774. PMC: 3144240. DOI: 10.1371/journal.pone.0022774. View

Ludvigsson J, Bai J, Biagi F, Card T, Ciacci C, Ciclitira P . Diagnosis and management of adult coeliac disease: guidelines from the British Society of Gastroenterology. Gut. 2014; 63(8):1210-28. PMC: 4112432. DOI: 10.1136/gutjnl-2013-306578. View

Meloni A, Mandas C, Jores R, Congia M . Prevalence of autoimmune thyroiditis in children with celiac disease and effect of gluten withdrawal. J Pediatr. 2009; 155(1):51-5, 55.e1. DOI: 10.1016/j.jpeds.2009.01.013. View

Dore M, Pes G, Dettori I, Villanacci V, Manca A, Realdi G . Clinical and genetic profile of patients with seronegative coeliac disease: the natural history and response to gluten-free diet. BMJ Open Gastroenterol. 2017; 4(1):e000159. PMC: 5606118. DOI: 10.1136/bmjgast-2017-000159. View

10.

Sardu C, Cocco E, Mereu A, Massa R, Cuccu A, Marrosu M . Population based study of 12 autoimmune diseases in Sardinia, Italy: prevalence and comorbidity. PLoS One. 2012; 7(3):e32487. PMC: 3292563. DOI: 10.1371/journal.pone.0032487. View

11.

Ludvigsson J, Ludvigsson J, Ekbom A, Montgomery S . Celiac disease and risk of subsequent type 1 diabetes: a general population cohort study of children and adolescents. Diabetes Care. 2006; 29(11):2483-8. DOI: 10.2337/dc06-0794. View

12.

Rubio-Tapia A, Hill I, Kelly C, Calderwood A, Murray J . ACG clinical guidelines: diagnosis and management of celiac disease. Am J Gastroenterol. 2013; 108(5):656-76. PMC: 3706994. DOI: 10.1038/ajg.2013.79. View

13.

Ianiro G, Bibbo S, Pecere S, Gasbarrini A, Cammarota G . Current technologies for the endoscopic assessment of duodenal villous pattern in celiac disease. Comput Biol Med. 2015; 65:308-14. DOI: 10.1016/j.compbiomed.2015.04.033. View

14.

Dore M, Cuccu M, Pes G, Mameli L, Manca A, Vidili G . [Clinical pattern of celiac disease in a population residing in North Sardinia (Italy)]. Recenti Prog Med. 2012; 103(12):564-9. DOI: 10.1701/1206.13357. View

15.

Tommasini A, Not T, Kiren V, Baldas V, Santon D, Trevisiol C . Mass screening for coeliac disease using antihuman transglutaminase antibody assay. Arch Dis Child. 2004; 89(6):512-5. PMC: 1719951. DOI: 10.1136/adc.2003.029603. View

16.

Ianiro G, Bibbo S, Bruno G, Ricci R, Arena V, Gasbarrini A . Prior Misdiagnosis of Celiac Disease Is Common Among Patients Referred to a Tertiary Care Center: A Prospective Cohort Study. Clin Transl Gastroenterol. 2016; 7:e139. PMC: 4737868. DOI: 10.1038/ctg.2015.48. View

17.

Di Sabatino A, Corazza G . Coeliac disease. Lancet. 2009; 373(9673):1480-93. DOI: 10.1016/S0140-6736(09)60254-3. View

18.

Lundin K, Wijmenga C . Coeliac disease and autoimmune disease-genetic overlap and screening. Nat Rev Gastroenterol Hepatol. 2015; 12(9):507-15. DOI: 10.1038/nrgastro.2015.136. View

19.

Canova C, Pitter G, Ludvigsson J, Romor P, Zanier L, Zanotti R . Celiac Disease and Risk of Autoimmune Disorders: A Population-Based Matched Birth Cohort Study. J Pediatr. 2016; 174:146-152.e1. DOI: 10.1016/j.jpeds.2016.02.058. View

20.

Pes G, Tolu F, Bazzu M, Dore M . Cholesterol change in coeliac patients following gluten-free diet depends on baseline levels. Dig Liver Dis. 2014; 46(7):662-3. DOI: 10.1016/j.dld.2014.02.015. View