Core-shell Magnetoelectric Nanorobot - A Remotely Controlled Probe for Targeted Cell Manipulation

Overview

Journal Sci Rep

Specialty Science

Date 2018 Jan 31

PMID 29379076

Citations 10

Authors

Soutik Betal

Amit Kumar Saha

Eduardo Ortega

Moumita Dutta

Anand Kumar Ramasubramanian

Amar Singh Bhalla

Ruyan Guo

Affiliations

Soon will be listed here.

Abstract

We have developed a remotely controlled dynamic process of manipulating targeted biological live cells using fabricated core-shell nanocomposites, which comprises of single crystalline ferromagnetic cores (CoFeO) coated with crystalline ferroelectric thin film shells (BaTiO). We demonstrate them as a unique family of inorganic magnetoelectric nanorobots (MENRs), controlled remotely by applied a.c. or d.c. magnetic fields, to perform cell targeting, permeation, and transport. Under a.c. magnetic field excitation (50 Oe, 60 Hz), the MENR acts as a localized electric periodic pulse generator and can permeate a series of misaligned cells, while aligning them to an equipotential mono-array by inducing inter-cellular signaling. Under a.c. magnetic field (40 Oe, 30 Hz) excitation, MENRs can be dynamically driven to a targeted cell, avoiding untargeted cells in the path, irrespective of cell density. D.C. magnetic field (-50 Oe) excitation causes the MENRs to act as thrust generator and exerts motion in a group of cells.

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