Generation of B Suppressor Cells by Phytohaemagglutinin

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1986 Mar 1

PMID 2937719

Citations 2

Authors

R Farkas

Y Manor

A Klajman

Affiliations

Soon will be listed here.

Abstract

Activation by phytohaemagglutinin-P (PHA-P) of B cells from peripheral blood of healthy subjects generated B suppressor cells which inhibited allogeneic mixed lymphocyte reactions (MLR) and PHA-induced DNA synthesis. Their action was direct, that is, not mediated through the induction of T suppressor cells. The finding that B cells can be induced by PHA to become highly effective suppressor cells may have important clinical and experimental implications.

Citing Articles

Immune suppression induced by Actinobacillus actinomycetemcomitans: effects on immunoglobulin production by human B cells.

Shenker B, VITALE L, Welham D Infect Immun. 1990; 58(12):3856-62.

PMID: 2254014 PMC: 313746. DOI: 10.1128/iai.58.12.3856-3862.1990.

Appearance of the T-cell marker CD8 on B chronic lymphatic leukemia cells in long-term cultures.

Farkas R, Ben-Efraim S, Manor Y, Klajman A Cancer Immunol Immunother. 1991; 34(3):181-5.

PMID: 1836750 PMC: 11038522. DOI: 10.1007/BF01742310.

References

Tsukuda K, Tsukuda Y, Klein G . Suppressor T cells activated by lymphoblastoid cell lines inhibit pokeweed mitogen-induced immunoglobulin synthesis. Cell Immunol. 1981; 60(1):191-202. DOI: 10.1016/0008-8749(81)90259-8. View

Schulof R, Garofalo J, GOOD R, Gupta S . Concanavalin A-induced suppressor cell activity for T-cell proliferative responses: autologous and allogeneic suppression in aging humans. Cell Immunol. 1980; 56(1):80-8. DOI: 10.1016/0008-8749(80)90083-0. View

Gilbert K, Hoffmann M . Lymphokine-induced suppressor B cells. Immunology. 1982; 46(3):545-53. PMC: 1555309. View

Matsumoto T, Nakano M, Shibata M . Suppression of the polyclonal B-cell response to lipopolysaccharide by concanavalin-A-treated non-T cells in vitro. Immunology. 1982; 47(4):651-61. PMC: 1555555. View

Rabellino E, Colon S, Grey H, UNANUE E . Immunoglobulins on the surface of lymphocytes. I. Distribution and quantitation. J Exp Med. 1971; 133(1):156-67. PMC: 2138891. DOI: 10.1084/jem.133.1.156. View

Yam L, Li C, CROSBY W . Cytochemical identification of monocytes and granulocytes. Am J Clin Pathol. 1971; 55(3):283-90. DOI: 10.1093/ajcp/55.3.283. View

Basten A, Miller J, Sprent J, Cheers C . Cell-to-cell interaction in the immune response. X. T-cell-dependent suppression in tolerant mice. J Exp Med. 1974; 140(1):199-217. PMC: 2139698. DOI: 10.1084/jem.140.1.199. View

Zembala M, Asherson G, Noworolski J, Mayhew B . Contact sensitivity to picryl chloride: the occurrence of B suppressor cells in the lymph nodes and spleen of immunized mice. Cell Immunol. 1976; 25(2):266-78. DOI: 10.1016/0008-8749(76)90117-9. View

Moretta L, Ferrarini M, Durante M, Mingari M . Expression of a receptor for IgM by human T cells in vitro. Eur J Immunol. 1975; 5(8):565-9. DOI: 10.1002/eji.1830050812. View

10.

Kurnick J, Bell C, Grey H . PHA-induced activation of suppressor cells in normal human peripheral blood lymphocytes. Scand J Immunol. 1976; 5(6-7):771-8. DOI: 10.1111/j.1365-3083.1976.tb03026.x. View

11.

Neta R, SALVIN S . T and B lymphocytes in the regulation of delayed hypersensitivity. J Immunol. 1976; 117(5 Pt.2):2014-20. View

12.

Steinberg A, Klassen L . Role of suppressor T cells in lymphopoietic disorders. Clin Haematol. 1977; 6(2):439-78. View

13.

Klajman A, Becker M, Farkash R, Steiner Z . Xenogenic response of human peripheral blood lymphocytes against murine cells in vitro. J Immunol Methods. 1978; 24(1-2):9-18. DOI: 10.1016/0022-1759(78)90080-7. View

14.

Lobo P, Spencer C . Inhibition of humoral and cell-mediated immune responses in man by distinct suppressor cell systems. J Clin Invest. 1979; 63(6):1157-63. PMC: 372063. DOI: 10.1172/JCI109409. View

15.

Rice L, Laughter A, TWOMEY J . Three suppressor systems in human blood that modulate lymphoproliferation. J Immunol. 1979; 122(3):991-6. View

16.

Tosato G, Magrath I, Koski I, Dooley N, Blaese M . Activation of suppressor T cells during Epstein-Barr-virus-induced infectious mononucleosis. N Engl J Med. 1979; 301(21):1133-7. DOI: 10.1056/NEJM197911223012101. View

17.

Koenig S, Hoffmann M . Bacterial lipopolysaccharide activates suppressor B lymphocytes. Proc Natl Acad Sci U S A. 1979; 76(9):4608-12. PMC: 411628. DOI: 10.1073/pnas.76.9.4608. View

18.

Bacigalupo A, Podesta M, Mingari M, Moretta L, Van Lint M, Marmont A . Immune suppression of hematopoiesis in aplastic anemia: activity of T-gamma lymphocytes. J Immunol. 1980; 125(4):1449-53. View

19.

Becker M, Drucker I, Farkas R, Steiner Z, Klajman A . Monocyte-mediated regulation of cellular immunity in humans: loss of suppressor activity with ageing. Clin Exp Immunol. 1981; 45(2):439-46. PMC: 1537387. View