Perspectives on Systems Modeling of Human Peripheral Blood Mononuclear Cells

Overview

Journal Front Mol Biosci

Specialty Biology

Date 2018 Jan 30

PMID 29376056

Citations 42

Authors

Partho Sen

Esko Kemppainen

Matej Oresic

Affiliations

Soon will be listed here.

Abstract

Human peripheral blood mononuclear cells (PBMCs) are the key drivers of the immune responses. These cells undergo activation, proliferation and differentiation into various subsets. During these processes they initiate metabolic reprogramming, which is coordinated by specific gene and protein activities. PBMCs as a model system have been widely used to study metabolic and autoimmune diseases. Herein we review various omics and systems-based approaches such as transcriptomics, epigenomics, proteomics, and metabolomics as applied to PBMCs, particularly T helper subsets, that unveiled disease markers and the underlying mechanisms. We also discuss and emphasize several aspects of T cell metabolic modeling in healthy and disease states using genome-scale metabolic models.

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