The Host-Pathogen-Extrinsic Factors in Tuberculosis: Modulating Inflammation and Clinical Outcomes

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2018 Jan 30

PMID 29375571

Citations 14

Authors

Helder Novais Bastos

Nuno S Osorio

Sebastien Gagneux

Inaki Comas

Margarida Saraiva

Affiliations

Soon will be listed here.

Abstract

The already enormous burden caused by tuberculosis (TB) will be further aggravated by the association of this disease with modern epidemics, as human immunodeficiency virus and diabetes. Furthermore, the increasingly aging population and the wider use of suppressive immune therapies hold the potential to enhance the incidence of TB. New preventive and therapeutic strategies based on recent advances on our understanding of TB are thus needed. In particular, understanding the intricate network of events modulating inflammation in TB will help to build more effective vaccines and host-directed therapies to stop TB. This review integrates the impact of host, pathogen, and extrinsic factors on inflammation and the almost scientifically unexplored complexity emerging from the interactions between these three factors. We highlight the exciting data showing a contribution of this for the clinical outcome of TB and the need of incorporating it when developing novel strategies to rewire the immune response in TB.

Citing Articles

The impact of single-cell genomics on the field of mycobacterial infection.

Geraldes I, Fernandes M, Fraga A, Osorio N Front Microbiol. 2022; 13:989464.

PMID: 36246265 PMC: 9562642. DOI: 10.3389/fmicb.2022.989464.

Acute Phase Proteins Are Baseline Predictors of Tuberculosis Treatment Failure.

Kumar N, Moideen K, Nancy A, Viswanathan V, Thiruvengadam K, Sivakumar S Front Immunol. 2021; 12:731878.

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The Sputum Microbiome in Pulmonary Tuberculosis and Its Association With Disease Manifestations: A Cross-Sectional Study.

Ticlla M, Hella J, Hiza H, Sasamalo M, Mhimbira F, Rutaihwa L Front Microbiol. 2021; 12:633396.

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Cathepsins and Their Endogenous Inhibitors in Host Defense During and HIV Infection.

Anes E, Azevedo-Pereira J, Pires D Front Immunol. 2021; 12:726984.

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Epidemiology of Mycobacterium tuberculosis lineages and strain clustering within urban and peri-urban settings in Ethiopia.

Taye H, Alemu K, Mihret A, Ayalew S, Hailu E, Wood J PLoS One. 2021; 16(7):e0253480.

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