Action of Cathepsin D on Human Beta-lipotropin: a Possible Source of Human "beta-melanotropin"

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1979 Dec 1

PMID 293708

Citations 6

Authors

E Barat

A Patthy

L Graf

Affiliations

Soon will be listed here.

Abstract

Highly purified calf brain cathepsin D (EC 3.4.23.5) selectively splits the Leu77-Phe78 and Ala36-Ala37 peptide bonds of human beta-lipotropin. It is suggested that the formation of human "beta-melanotropin" from gamma-lipotropin, and that of gamma-endorphin from beta-endorphin, is due to the action of cathepsin D during isolation procedures.

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