Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio Can Predict the Severity of Gallstone Pancreatitis

Overview

Journal BMC Gastroenterol

Publisher Biomed Central

Specialty Gastroenterology

Date 2018 Jan 27

PMID 29370777

Citations 22

Authors

Seung Kook Cho

Saehyun Jung

Kyong Joo Lee

Jae Woo Kim

Affiliations

Soon will be listed here.

Abstract

Background: Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) predict severity in various diseases. In this study, we evaluated the value of NLR and PLR as prognostic factors in acute pancreatitis (AP).

Methods: Patients with AP were prospectively enrolled from March 2014 to September 2016 at Yonsei University Wonju College of Medicine. NLR and PLR were obtained at admission and were compared with other known prognostic scoring systems.

Results: A total of 243 patients were enrolled with an etiology of gallstone (n = 134) or alcohol (n = 109). NLR (17.7 ± 18.3 vs. 8.8 ± 8.4, P < 0.001) and PLR (344.1 ± 282.6 vs. 177.8 ± 150.1, P < 0.001) were significantly higher in the gallstone AP group than in the alcoholic AP group. For gallstone AP, NLR and PLR were significantly higher in severe AP, whereas high NLR and PLR were not related to severe AP in alcoholic AP. For the gallstone AP group, NLR and PLR demonstrated a predictive value significantly superior to C-reactive protein (CRP), whereas NLR, PLR, and CRP were not significant predictors for alcoholic AP.

Conclusion: Our study demonstrated that NLR and PLR can predict the severity of AP, but only in gallstone AP.

Citing Articles

Inflammatory burden index (IBI) and body roundness index (BRI) in gallstone risk prediction: insights from NHANES 2017-2020.

Gu Y, Zhou Z, Zhao X, Ye X, Qin K, Liu J Lipids Health Dis. 2025; 24(1):63.

PMID: 39985035 PMC: 11844043. DOI: 10.1186/s12944-025-02472-2.

Association between Neutrophil-to-high-density lipoprotein-cholesterol ratio and gallstones: insights from the national health and nutrition examination survey (2017-2020).

Ma D, Ma H, Li Y, Yang L Lipids Health Dis. 2024; 23(1):355.

PMID: 39482705 PMC: 11526654. DOI: 10.1186/s12944-024-02349-w.

Clinical study of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in hypertriglyceridemia-induced acute pancreatitis and acute biliary pancreatitis with persistent organ failure.

Xu M, Xu J, Gao X, Mo S, Xing J, Liu J World J Gastrointest Surg. 2024; 16(6):1647-1659.

PMID: 38983313 PMC: 11230014. DOI: 10.4240/wjgs.v16.i6.1647.

NLR48 is Better Than CRP, and mCTSI, and Similar to BISAP and SOFA Scores for Mortality Prediction in Acute Pancreatitis: A Comparison of 6 Scores.

Cazacu S, Parscoveanu M, Cartu D, Moraru E, Rogoveanu I, Ungureanu B J Inflamm Res. 2023; 16:4793-4804.

PMID: 37881651 PMC: 10596122. DOI: 10.2147/JIR.S432408.

Acute peripancreatic fluid collection in acute pancreatitis: Incidence, outcome, and association with inflammatory markers.

Solakoglu T, Kucukmetin N, Akar M, Koseoglu H Saudi J Gastroenterol. 2023; 29(4):225-232.

PMID: 37470666 PMC: 10445500. DOI: 10.4103/sjg.sjg_443_22.

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