MicroRNA-379-5p is Associate with Biochemical Premature Ovarian Insufficiency Through PARP1 and XRCC6

Overview

Journal Cell Death Dis

Specialties Cell Biology
General Medicine

Date 2018 Jan 26

PMID 29367615

Citations 23

Authors

Yujie Dang

Xiaoyan Wang

Yajing Hao

Xinyue Zhang

Shidou Zhao

Jinlong Ma

Yingying Qin

Zi-Jiang Chen

Affiliations

Soon will be listed here.

Abstract

Premature ovarian insufficiency (POI) imposes great challenges on women's fertility and lifelong health. POI is highly heterogeneous and encompasses occult, biochemical, and overt stages. MicroRNAs (miRNAs) are negative regulators of gene expression, whose roles in physiology and diseases like cancers and neurological disorders have been recognized, but little is known about the miRNAs profile and functional relevance in biochemical POI (bPOI). In this study, the expression of miRNAs and mRNAs in granulosa cells (GCs) of bPOI women was determined by two microarrays, respectively. MiR-379-5p, PARP1, and XRCC6 were differentially expressed in GCs of bPOI as revealed by microarrays. Subsequently, functional studies demonstrated that miR-379-5p overexpression inhibited granulosa cell proliferation and attenuated DNA repair efficiency. Furthermore, both PARP1 and XRCC6 showed lower levels in GCs from patients with bPOI and were identified as executives of miR-379-5p. Therefore, our data first uncovered potentially pathogenic miR-379-5p and two novel targets PARP1 and XRCC6 in bPOI, which corroborated the significance of DNA repair for POI, and brought up an epigenetic explanation for the disease.

Citing Articles

MicroRNA-379-5p attenuates cancer stem cells and reduces cisplatin resistance in ovarian cancer by regulating RAD18/Polη axis.

Shukla D, Mishra S, Mandal T, Charan M, Verma A, Khan M Cell Death Dis. 2025; 16(1):140.

PMID: 40016217 PMC: 11868536. DOI: 10.1038/s41419-025-07430-5.

The Functions and Implications of MicroRNAs in Premature Ovarian Insufficiency.

Gao H, Cao X, Hua H, Zhu H Mol Genet Genomic Med. 2025; 13(2):e70074.

PMID: 39959946 PMC: 11831191. DOI: 10.1002/mgg3.70074.

USP14 inhibition promotes DNA damage repair and represses ovarian granulosa cell senescence in premature ovarian insufficiency.

Ma L, Wang A, Lai Y, Zhang J, Zhang X, Chen S J Transl Med. 2024; 22(1):834.

PMID: 39261935 PMC: 11389224. DOI: 10.1186/s12967-024-05636-3.

Genetic insights into the complexity of premature ovarian insufficiency.

Nie L, Wang X, Wang S, Hong Z, Wang M Reprod Biol Endocrinol. 2024; 22(1):94.

PMID: 39095891 PMC: 11295921. DOI: 10.1186/s12958-024-01254-2.

Granulosa Cells-Related MicroRNAs in Ovarian Diseases: Mechanism, Facts and Perspectives.

Xiao S, Du J, Yuan G, Luo X, Song L Reprod Sci. 2024; 31(12):3635-3650.

PMID: 38594585 DOI: 10.1007/s43032-024-01523-w.

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