Insights into Inflammatory Priming of Mesenchymal Stromal Cells: Functional Biological Impacts

Overview

Journal Inflamm Res

Specialties Allergy & Immunology
Pathology

Date 2018 Jan 25

PMID 29362849

Citations 51

Authors

Mehdi Najar

Mohammad Krayem

Makram Merimi

Arsene Burny

Nathalie Meuleman

Dominique Bron

Gordana Raicevic

Laurence Lagneaux

Affiliations

Soon will be listed here.

Abstract

Mesenchymal stromal cells (MSCs) are multipotent adult cells with relevant biological properties making them interesting tools for cell-based therapy. These cells have the ability to home to sites of injury and secrete bioactive factors as part of their therapeutic functions. However, depending on the local environment, diverse functions of MSCs can be modulated and thus can influence their therapeutic value. The specific cytokine milieu within the site of inflammation is vital in determining the fate and cell behaviors of MSCs. Indeed, inflammatory signals (called as inflammatory priming), may induce critical changes on the phenotype, multilineage potential, hematopoietic support and immunomodulatory capacity of MSCs. Thus, for appropriate clinical application of MSCs, it is important to well know and understand these effects. In summary, investigating MSC interactions with the inflammatory environment is necessary to empower the therapeutic value of MSCs.

Citing Articles

Improving the therapeutic profile of MSCs: Cytokine priming reduces donor-dependent heterogeneity and enhances their immunomodulatory capacity.

Valencia J, Yanez R, Muntion S, Fernandez-Garcia M, Martin-Rufino J, Zapata A Front Immunol. 2025; 16:1473788.

PMID: 40034706 PMC: 11872697. DOI: 10.3389/fimmu.2025.1473788.

The Immune-Centric Revolution Translated into Clinical Application: Peripheral Blood Mononuclear Cell (PBMNC) Therapy in Diabetic Patients with No-Option Critical Limb-Threatening Ischemia (NO-CLTI)-Rationale and Meta-Analysis of Observational....

Rehak L, Giurato L, Monami M, Meloni M, Scatena A, Panunzi A J Clin Med. 2024; 13(23).

PMID: 39685690 PMC: 11642624. DOI: 10.3390/jcm13237230.

Poly (I:C) increases the expression of and genes in exosomes isolated from human Wharton's jelly mesenchymal stem cells.

Abbaspour M, Ghafourian Boroujerdnia M, Tahoori M, Oraki Kohshour M, Dehcheshmeh M, Amirzadeh S Heliyon. 2024; 10(15):e35343.

PMID: 39170483 PMC: 11336598. DOI: 10.1016/j.heliyon.2024.e35343.

The Immunological Profile of Adipose Mesenchymal Stromal/Stem Cells after Cell Expansion and Inflammatory Priming.

Buyl K, Merimi M, Rodrigues R, Rahmani S, Fayyad-Kazan M, Bouhtit F Biomolecules. 2024; 14(7).

PMID: 39062566 PMC: 11275169. DOI: 10.3390/biom14070852.

Hyaluronic acid stimulation of stem cells for cardiac repair: a cell-free strategy for myocardial infarct.

Jeong S, Park B, Kim J, Lee S, You H, Lee J J Nanobiotechnology. 2024; 22(1):149.

PMID: 38570846 PMC: 10993512. DOI: 10.1186/s12951-024-02410-x.

References

Feghali C, Wright T . Cytokines in acute and chronic inflammation. Front Biosci. 1997; 2:d12-26. DOI: 10.2741/a171. View

Amouzegar A, Mittal S, Sahu A, Sahu S, Chauhan S . Mesenchymal Stem Cells Modulate Differentiation of Myeloid Progenitor Cells During Inflammation. Stem Cells. 2017; 35(6):1532-1541. PMC: 5446294. DOI: 10.1002/stem.2611. View

Sonomoto K, Yamaoka K, Oshita K, Fukuyo S, Zhang X, Nakano K . Interleukin-1β induces differentiation of human mesenchymal stem cells into osteoblasts via the Wnt-5a/receptor tyrosine kinase-like orphan receptor 2 pathway. Arthritis Rheum. 2012; 64(10):3355-63. DOI: 10.1002/art.34555. View

Guan Q, Ezzati P, Spicer V, Krokhin O, Wall D, Wilkins J . Interferon γ induced compositional changes in human bone marrow derived mesenchymal stem/stromal cells. Clin Proteomics. 2017; 14:26. PMC: 5501357. DOI: 10.1186/s12014-017-9161-1. View

Duque G, Huang D, Macoritto M, Rivas D, Yang X, Ste-Marie L . Autocrine regulation of interferon gamma in mesenchymal stem cells plays a role in early osteoblastogenesis. Stem Cells. 2008; 27(3):550-8. DOI: 10.1634/stemcells.2008-0886. View

Klinker M, Marklein R, Lo Surdo J, Wei C, Bauer S . Morphological features of IFN-γ-stimulated mesenchymal stromal cells predict overall immunosuppressive capacity. Proc Natl Acad Sci U S A. 2017; 114(13):E2598-E2607. PMC: 5380055. DOI: 10.1073/pnas.1617933114. View

English K, Barry F, Field-Corbett C, Mahon B . IFN-gamma and TNF-alpha differentially regulate immunomodulation by murine mesenchymal stem cells. Immunol Lett. 2007; 110(2):91-100. DOI: 10.1016/j.imlet.2007.04.001. View

Hass R, Kasper C, Bohm S, Jacobs R . Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC. Cell Commun Signal. 2011; 9:12. PMC: 3117820. DOI: 10.1186/1478-811X-9-12. View

Naveiras O, Nardi V, Wenzel P, Hauschka P, Fahey F, Daley G . Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment. Nature. 2009; 460(7252):259-63. PMC: 2831539. DOI: 10.1038/nature08099. View

10.

Meisel R, Zibert A, Laryea M, Gobel U, Daubener W, Dilloo D . Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation. Blood. 2004; 103(12):4619-21. DOI: 10.1182/blood-2003-11-3909. View

11.

Hess K, Ushmorov A, Fiedler J, Brenner R, Wirth T . TNFalpha promotes osteogenic differentiation of human mesenchymal stem cells by triggering the NF-kappaB signaling pathway. Bone. 2009; 45(2):367-76. DOI: 10.1016/j.bone.2009.04.252. View

12.

Barry F, Murphy J . Mesenchymal stem cells: clinical applications and biological characterization. Int J Biochem Cell Biol. 2004; 36(4):568-84. DOI: 10.1016/j.biocel.2003.11.001. View

13.

Ren G, Su J, Zhang L, Zhao X, Ling W, Lhuillie A . Species variation in the mechanisms of mesenchymal stem cell-mediated immunosuppression. Stem Cells. 2009; 27(8):1954-62. DOI: 10.1002/stem.118. View

14.

Raicevic G, Najar M, Stamatopoulos B, De Bruyn C, Meuleman N, Bron D . The source of human mesenchymal stromal cells influences their TLR profile as well as their functional properties. Cell Immunol. 2011; 270(2):207-16. DOI: 10.1016/j.cellimm.2011.05.010. View

15.

Greenblatt M, Shim J, Zou W, Sitara D, Schweitzer M, Hu D . The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice. J Clin Invest. 2010; 120(7):2457-73. PMC: 2898605. DOI: 10.1172/JCI42285. View

16.

Zimmermann J, Hettiaratchi M, McDevitt T . Enhanced Immunosuppression of T Cells by Sustained Presentation of Bioactive Interferon-γ Within Three-Dimensional Mesenchymal Stem Cell Constructs. Stem Cells Transl Med. 2017; 6(1):223-237. PMC: 5442746. DOI: 10.5966/sctm.2016-0044. View

17.

Xi J, Yan X, Zhou J, Yue W, Pei X . Mesenchymal stem cells in tissue repairing and regeneration: Progress and future. Burns Trauma. 2016; 1(1):13-20. PMC: 4994498. DOI: 10.4103/2321-3868.113330. View

18.

Le Blanc K, Tammik C, Rosendahl K, Zetterberg E, Ringden O . HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells. Exp Hematol. 2003; 31(10):890-6. DOI: 10.1016/s0301-472x(03)00110-3. View

19.

Pontikoglou C, Langonne A, Ba M, Varin A, Rosset P, Charbord P . CD200 expression in human cultured bone marrow mesenchymal stem cells is induced by pro-osteogenic and pro-inflammatory cues. J Cell Mol Med. 2016; 20(4):655-65. PMC: 5125749. DOI: 10.1111/jcmm.12752. View

20.

Wang Y, Chen X, Cao W, Shi Y . Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications. Nat Immunol. 2014; 15(11):1009-16. DOI: 10.1038/ni.3002. View