Is the Location of the Tumor Another Prognostic Factor for Patients With Colon Cancer?

Overview

Journal Ann Coloproctol

Date 2018 Jan 23

PMID 29354603

Citations 11

Authors

Myung-Kyu Jung

Ui Sup Shin

Young-Jun Ki

Yong-Bae Kim

Sun-Mi Moon

Se-Jin Sung

Affiliations

Soon will be listed here.

Abstract

Purpose: In this study, we investigated both the characteristics of right colon cancer (RTCC) in comparison with those of left colon cancer (LTCC) and the impact of the location of the colon cancer on the prognosis.

Methods: We retrospectively analyzed the cases of 974 patients with nonmetastatic colon cancer who had undergone surgery with a curative intent from January 2001 to December 2011. RTCC was defined as a tumor located proximal to the splenic flexure. The characteristics of RTCC cancer were investigated by using descriptive analyses, and their impacts on the prognosis were assessed by using a Cox multivariate regression.

Results: Compared to LTCC, RTCC showed a female-dominant feature, and an undifferentiated pathology was more frequently observed. The number of lymph nodes retrieved from patients with RTCC was significantly higher than that retrieved from patients with LTCC. During 75 months of follow-up, peritoneal recurrence was more common in patients with RTCC than it was in patients with LTCC, and among the patients with stage III colon cancer, the disease-free and the overall survival rates were significantly worse in patients with RTCC. After adjustments with the other prognostic factors associated with colon cancer had been made, a tumor located at the right colon was found to be independently associated with poor prognosis.

Conclusion: RTCC showed unique clinicopathologic features and was associated with a poorer prognosis.

Citing Articles

Colorectal Cancer: Disease Process, Current Treatment Options, and Future Perspectives.

Adebayo A, Agbaje K, Adesina S, Olajubutu O Pharmaceutics. 2023; 15(11).

PMID: 38004598 PMC: 10674471. DOI: 10.3390/pharmaceutics15112620.

Frequency of HER2 Expression, MMR Deficiency, and PI3KCA Mutation in Pretreated Surgical Specimens of Patients with Esophageal Squamous Cell Carcinoma in Iran Cancer Institute.

Salarvand Farzaneh Bagheri S, Gholizadeh M, Sharifi S, Panahi P, Esmati E, Lashkari M Iran J Pathol. 2023; 18(1):96-103.

PMID: 37383157 PMC: 10293601. DOI: 10.30699/IJP.2023.563358.2989.

Prognostic Significance of MRE11 Overexpression in Colorectal Cancer Patients.

Ho V, Chung L, Wilkinson K, Lea V, Lim S, Abubakar A Cancers (Basel). 2023; 15(9).

PMID: 37173905 PMC: 10177562. DOI: 10.3390/cancers15092438.

Comparison of prolonged postoperative ileus between laparoscopic right and left colectomy under enhanced recovery after surgery: a propensity score matching analysis.

Lin Z, Yang C, Wang Y, Yan M, Zheng H World J Surg Oncol. 2022; 20(1):68.

PMID: 35246150 PMC: 8895612. DOI: 10.1186/s12957-022-02504-6.

Disparities in Healthcare: Evaluation of Equity in Access to Surveillance Colonoscopy After Hemicolectomy in Patients With Colon Cancer During the COVID-19 Pandemic.

Singh R, Patel E Cureus. 2022; 14(1):e21582.

PMID: 35228940 PMC: 8867528. DOI: 10.7759/cureus.21582.

References

Powell A, Wallace R, McKee R, Anderson J, Going J, Edwards J . The relationship between tumour site, clinicopathological characteristics and cancer-specific survival in patients undergoing surgery for colorectal cancer. Colorectal Dis. 2012; 14(12):1493-9. DOI: 10.1111/j.1463-1318.2012.03048.x. View

Benedix F, Kube R, Meyer F, Schmidt U, Gastinger I, Lippert H . Comparison of 17,641 patients with right- and left-sided colon cancer: differences in epidemiology, perioperative course, histology, and survival. Dis Colon Rectum. 2009; 53(1):57-64. DOI: 10.1007/DCR.0b013e3181c703a4. View

Merok M, Ahlquist T, Royrvik E, Tufteland K, Hektoen M, Sjo O . Microsatellite instability has a positive prognostic impact on stage II colorectal cancer after complete resection: results from a large, consecutive Norwegian series. Ann Oncol. 2012; 24(5):1274-82. PMC: 3629894. DOI: 10.1093/annonc/mds614. View

Tejpar S, Stintzing S, Ciardiello F, Tabernero J, Van Cutsem E, Beier F . Prognostic and Predictive Relevance of Primary Tumor Location in Patients With RAS Wild-Type Metastatic Colorectal Cancer: Retrospective Analyses of the CRYSTAL and FIRE-3 Trials. JAMA Oncol. 2016; 3(2):194-201. PMC: 7505121. DOI: 10.1001/jamaoncol.2016.3797. View

Lindblom A . Different mechanisms in the tumorigenesis of proximal and distal colon cancers. Curr Opin Oncol. 2001; 13(1):63-9. DOI: 10.1097/00001622-200101000-00013. View

Pai R, Jayachandran P, Koong A, Chang D, Kwok S, Ma L . BRAF-mutated, microsatellite-stable adenocarcinoma of the proximal colon: an aggressive adenocarcinoma with poor survival, mucinous differentiation, and adverse morphologic features. Am J Surg Pathol. 2012; 36(5):744-52. PMC: 6362986. DOI: 10.1097/PAS.0b013e31824430d7. View

Shen H, Yang J, Huang Q, Jiang M, Tan Y, Fu J . Different treatment strategies and molecular features between right-sided and left-sided colon cancers. World J Gastroenterol. 2015; 21(21):6470-8. PMC: 4458758. DOI: 10.3748/wjg.v21.i21.6470. View

Jung K, Won Y, Kong H, Oh C, Lee D, Lee J . Prediction of cancer incidence and mortality in Korea, 2014. Cancer Res Treat. 2014; 46(2):124-30. PMC: 4022820. DOI: 10.4143/crt.2014.46.2.124. View

Bufill J . Colorectal cancer: evidence for distinct genetic categories based on proximal or distal tumor location. Ann Intern Med. 1990; 113(10):779-88. DOI: 10.7326/0003-4819-113-10-779. View

10.

Brule S, Jonker D, Karapetis C, OCallaghan C, Moore M, Wong R . Location of colon cancer (right-sided versus left-sided) as a prognostic factor and a predictor of benefit from cetuximab in NCIC CO.17. Eur J Cancer. 2015; 51(11):1405-14. DOI: 10.1016/j.ejca.2015.03.015. View

11.

Warschkow R, Sulz M, Marti L, Tarantino I, Schmied B, Cerny T . Better survival in right-sided versus left-sided stage I - III colon cancer patients. BMC Cancer. 2016; 16:554. PMC: 4964057. DOI: 10.1186/s12885-016-2412-0. View

12.

Oh J, Kim D, Lee H, Lee H, Lee S, Jang J . Microsatellite instability testing in Korean patients with colorectal cancer. Fam Cancer. 2012; 11(3):459-66. DOI: 10.1007/s10689-012-9536-4. View

13.

Yokota J . Tumor progression and metastasis. Carcinogenesis. 2000; 21(3):497-503. DOI: 10.1093/carcin/21.3.497. View

14.

Worthley D, Whitehall V, Spring K, Leggett B . Colorectal carcinogenesis: road maps to cancer. World J Gastroenterol. 2007; 13(28):3784-91. PMC: 4611209. DOI: 10.3748/wjg.v13.i28.3784. View

15.

Ishihara S, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K . Prognostic impact of tumor location in stage IV colon cancer: a propensity score analysis in a multicenter study. Int J Surg. 2014; 12(9):925-30. DOI: 10.1016/j.ijsu.2014.07.270. View

16.

Jang M, Kim S, Hwang D, Kim W, Lim S, Kim W . BRAF-Mutated Colorectal Cancer Exhibits Distinct Clinicopathological Features from Wild-Type BRAF-Expressing Cancer Independent of the Microsatellite Instability Status. J Korean Med Sci. 2016; 32(1):38-46. PMC: 5143296. DOI: 10.3346/jkms.2017.32.1.38. View

17.

Nawa T, Kato J, Kawamoto H, Okada H, Yamamoto H, Kohno H . Differences between right- and left-sided colon cancer in patient characteristics, cancer morphology and histology. J Gastroenterol Hepatol. 2007; 23(3):418-23. DOI: 10.1111/j.1440-1746.2007.04923.x. View

18.

Weiss J, Pfau P, OConnor E, King J, LoConte N, Kennedy G . Mortality by stage for right- versus left-sided colon cancer: analysis of surveillance, epidemiology, and end results--Medicare data. J Clin Oncol. 2011; 29(33):4401-9. PMC: 3221523. DOI: 10.1200/JCO.2011.36.4414. View

19.

Yaeger R, Cercek A, Chou J, Sylvester B, Kemeny N, Hechtman J . BRAF mutation predicts for poor outcomes after metastasectomy in patients with metastatic colorectal cancer. Cancer. 2014; 120(15):2316-24. PMC: 4928876. DOI: 10.1002/cncr.28729. View

20.

Chen D, Huang J, Liu K, Zhang L, Yang Z, Chuai Z . BRAFV600E mutation and its association with clinicopathological features of colorectal cancer: a systematic review and meta-analysis. PLoS One. 2014; 9(3):e90607. PMC: 3940924. DOI: 10.1371/journal.pone.0090607. View