Suppression of Murine NK Activity Induced by Corynebacterium Parvum: Further Characterization and Abrogation of Suppressor Cells

Overview

Journal Cancer Immunol Immunother

Specialties Allergy & Immunology
Oncology
Pharmacology

Date 1986 Jan 1

PMID 2935247

Citations 1

Authors

V K Milisauskas

G CUDKOWICZ

I Nakamura

Affiliations

Soon will be listed here.

Abstract

Formalin-killed Corynebacterium parvum (CP), given at a dose of 0.4-0.7 mg/mouse IV or IP, induced suppressor cells for NK activity in B6C3F1 mice. The suppressor cells belong to at least two different populations, plastic adherent and nonadherent, and were not depleted by antibodies specific for Thy-1.2, Iak, or NK-1.2 surface markers. Administration of p-I:C, an interferon-inducer, to animals 18 h before the assay did not affect the suppressor activity. Hypotonic shock treatment of splenocytes abrogated the in vitro suppressive activity, and subsequent reconstitution of the shock-treated cells with RBC failed to restore the suppressive activity. SJL/J mice, which have low NK activity, exhibited suppressor activity comparable to B6C3F1 mice following CP treatment, whereas CP-treated BALB/c athymic and euthymic mice showed a lower ability to generate suppressors for NK as compared to B6C3F1 mice.

Citing Articles

Role of gamma interferon in induction of natural killer activity by Legionella pneumophila in vitro and in an experimental murine infection model.

Blanchard D, Friedman H, Stewart 2nd W, Klein T, Djeu J Infect Immun. 1988; 56(5):1187-93.

PMID: 3128479 PMC: 259782. DOI: 10.1128/iai.56.5.1187-1193.1988.

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