Abnormal Retinal Function Associated with Fenretinide, a Synthetic Retinoid

Overview

Journal Arch Ophthalmol

Publisher American Medical Association

Specialty Ophthalmology

Date 1986 Jan 1

PMID 2935125

Citations 13

Authors

G L Peck

R C Caruso

M J Jaffe

J J DiGiovanna

E G GROSS

Affiliations

Soon will be listed here.

Abstract

Five patients with basal cell carcinoma received fenretinide. Two patients while receiving the drug had evidence of abnormal rod photoreceptor function that reversed rapidly on cessation of therapy. We speculate that fenretinide may interfere with the binding of vitamin A to opsin or with the transport of vitamin A.

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