Impact of Time-Restricted Feeding and Dawn-to-Sunset Fasting on Circadian Rhythm, Obesity, Metabolic Syndrome, and Nonalcoholic Fatty Liver Disease

Overview

Journal Gastroenterol Res Pract

Publisher Wiley

Specialty Gastroenterology

Date 2018 Jan 20

PMID 29348746

Citations 21

Authors

Ayse L Mindikoglu

Antone R Opekun

Sood K Gagan

Sridevi Devaraj

Affiliations

Soon will be listed here.

Abstract

Obesity now affects millions of people and places them at risk of developing metabolic syndrome, nonalcoholic fatty liver disease (NAFLD), and even hepatocellular carcinoma. This rapidly emerging epidemic has led to a search for cost-effective methods to prevent the metabolic syndrome and NAFLD as well as the progression of NAFLD to cirrhosis and hepatocellular carcinoma. In murine models, time-restricted feeding resets the hepatic circadian clock and enhances transcription of key metabolic regulators of glucose and lipid homeostasis. Studies of the effect of dawn-to-sunset Ramadan fasting, which is akin to time-restricted feeding model, have also identified significant improvement in body mass index, serum lipid profiles, and oxidative stress parameters. Based on the findings of studies conducted on human subjects, dawn-to-sunset fasting has the potential to be a cost-effective intervention for obesity, metabolic syndrome, and NAFLD.

Citing Articles

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References

Nematy M, Alinezhad-Namaghi M, Mahdavi Rashed M, Mozhdehifard M, Sajjadi S, Akhlaghi S . Effects of Ramadan fasting on cardiovascular risk factors: a prospective observational study. Nutr J. 2012; 11:69. PMC: 3487759. DOI: 10.1186/1475-2891-11-69. View

Bahammam A . Does Ramadan fasting affect sleep?. Int J Clin Pract. 2006; 60(12):1631-7. DOI: 10.1111/j.1742-1241.2005.00811.x. View

Lazo M, Hernaez R, Eberhardt M, Bonekamp S, Kamel I, Guallar E . Prevalence of nonalcoholic fatty liver disease in the United States: the Third National Health and Nutrition Examination Survey, 1988-1994. Am J Epidemiol. 2013; 178(1):38-45. PMC: 3698993. DOI: 10.1093/aje/kws448. View

Backhed F, Manchester J, Semenkovich C, Gordon J . Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc Natl Acad Sci U S A. 2007; 104(3):979-84. PMC: 1764762. DOI: 10.1073/pnas.0605374104. View

Mittal S, El-Serag H, Sada Y, Kanwal F, Duan Z, Temple S . Hepatocellular Carcinoma in the Absence of Cirrhosis in United States Veterans is Associated With Nonalcoholic Fatty Liver Disease. Clin Gastroenterol Hepatol. 2015; 14(1):124-31.e1. PMC: 4690789. DOI: 10.1016/j.cgh.2015.07.019. View

Wehr T, Aeschbach D, Duncan Jr W . Evidence for a biological dawn and dusk in the human circadian timing system. J Physiol. 2001; 535(Pt 3):937-51. PMC: 2278827. DOI: 10.1111/j.1469-7793.2001.t01-1-00937.x. View

Hatori M, Vollmers C, Zarrinpar A, DiTacchio L, Bushong E, Gill S . Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. Cell Metab. 2012; 15(6):848-60. PMC: 3491655. DOI: 10.1016/j.cmet.2012.04.019. View

Calle E, Rodriguez C, Walker-Thurmond K, Thun M . Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med. 2003; 348(17):1625-38. DOI: 10.1056/NEJMoa021423. View

Tilg H, Moschen A, Kaser A . Obesity and the microbiota. Gastroenterology. 2009; 136(5):1476-83. DOI: 10.1053/j.gastro.2009.03.030. View

10.

Adamovich Y, Rousso-Noori L, Zwighaft Z, Neufeld-Cohen A, Golik M, Kraut-Cohen J . Circadian clocks and feeding time regulate the oscillations and levels of hepatic triglycerides. Cell Metab. 2014; 19(2):319-30. PMC: 4261230. DOI: 10.1016/j.cmet.2013.12.016. View

11.

Zawawi T, Abdelwahab S . Altered cortisol levels in relation to Ramadan. Eur J Clin Nutr. 1988; 42(4):359-62. View

12.

Backhed F, Ding H, Wang T, Hooper L, Koh G, Nagy A . The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A. 2004; 101(44):15718-23. PMC: 524219. DOI: 10.1073/pnas.0407076101. View

13.

Bahijri S, Borai A, Ajabnoor G, Abdul Khaliq A, AlQassas I, Al-Shehri D . Relative metabolic stability, but disrupted circadian cortisol secretion during the fasting month of Ramadan. PLoS One. 2013; 8(4):e60917. PMC: 3630175. DOI: 10.1371/journal.pone.0060917. View

14.

Reppert S, Weaver D . Coordination of circadian timing in mammals. Nature. 2002; 418(6901):935-41. DOI: 10.1038/nature00965. View

15.

Goyal A, Terry P, Superak H, Nell-Dybdahl C, Chowdhury R, Phillips L . Melatonin supplementation to treat the metabolic syndrome: a randomized controlled trial. Diabetol Metab Syndr. 2015; 6:124. PMC: 4416300. DOI: 10.1186/1758-5996-6-124. View

16.

Benli Aksungar F, Eren A, Ure S, Teskin O, Ates G . Effects of intermittent fasting on serum lipid levels, coagulation status and plasma homocysteine levels. Ann Nutr Metab. 2005; 49(2):77-82. DOI: 10.1159/000084739. View

17.

Kvetnoi I, Raikhlin N, Tolkachev V . [Chromatographic detection of melatonin (5-methoxy-N-acetyltryptamine) and its biological precursors in enterochromaffin cells]. Dokl Akad Nauk SSSR. 1975; 221(1):226-7. View

18.

May A, Freedman D, Sherry B, Blanck H . Obesity - United States, 1999-2010. MMWR Suppl. 2013; 62(3):120-8. View

19.

Mendez-Hernandez P, Dosamantes-Carrasco L, Siani C, Pierlot R, Martinez-Gomez M, Rivera-Paredez B . Mealtime habits and risk of developing the metabolic syndrome or insulin resistance among Mexican adults. Br J Nutr. 2016; 116(10):1824-1833. PMC: 6752972. DOI: 10.1017/S0007114516003329. View

20.

Jouffe C, Cretenet G, Symul L, Martin E, Atger F, Naef F . The circadian clock coordinates ribosome biogenesis. PLoS Biol. 2013; 11(1):e1001455. PMC: 3536797. DOI: 10.1371/journal.pbio.1001455. View