Serum Uric Acid Levels in Patients with Amyotrophic Lateral Sclerosis: a Meta-analysis

Overview

Journal Sci Rep

Specialty Science

Date 2018 Jan 20

PMID 29348425

Citations 14

Authors

Fan Zhang

Qin Zhang

Yaqiong Ke

Jianbo Hao

Ling Lu

Nannan Lu

Xiling Chen

Affiliations

Soon will be listed here.

Abstract

The pathogenic mechanism of ALS remains unclear. However, increasing evidence has indicated that uric acid (UA) may play a protective role in the pathogenesis of ALS. The aim of this study was to evaluate the association between serum UA levels and ALS. A comprehensive literature search in PubMed, Embase, Web of Science, and Cochrane Library was conducted up to 31st August, 2017, using keywords. A random-effects model or fixed-effects model was used to calculate the pooled estimate according to the inter-group heterogeneity. Finally, we indentified 8 case-control and 3 cohort studies. The results indicated that patients with ALS had significant decreased levels of serum UA compared to healthy controls (standardized mean difference (SMD) = -0.72, 95% CI [-0.98,-0.46], P < 0.001). Increased serum UA levels were associated with lower all-cause mortality risk among ALS patients (risk ratio (RR) = 0.70, 95% CI [0.57, 0.87], P = 0.001). To summarize, there is an inverse association between serum UA levels and risk of death among ALS patients. Randomized controlled trials with high quality are required to elucidate the role of UA on ALS.

Citing Articles

The Impact of Serum Uric Acid on the Progression of Amyotrophic Lateral Sclerosis in Adults Aged 18 and Older: A Systematic Review.

Hussein S, Pingili S, Makkena V, Jaramillo A, Awosusi B, Ayyub J Cureus. 2023; 15(7):e42312.

PMID: 37614251 PMC: 10444204. DOI: 10.7759/cureus.42312.

Astrocytes: Dissecting Their Diverse Roles in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.

Valori C, Sulmona C, Brambilla L, Rossi D Cells. 2023; 12(11).

PMID: 37296571 PMC: 10252425. DOI: 10.3390/cells12111450.

Biologic targets of prescription medications and risk of neurodegenerative disease in United States Medicare beneficiaries.

Song Y, Racette B, Camacho-Soto A, Searles Nielsen S PLoS One. 2023; 18(5):e0285011.

PMID: 37195983 PMC: 10191296. DOI: 10.1371/journal.pone.0285011.

Elevated serum uric acid is associated with cognitive improvement in older American adults: A large, population-based-analysis of the NHANES database.

Geng R, Zhang Y, Liu M, Deng S, Ding J, Zhong H Front Aging Neurosci. 2022; 14:1024415.

PMID: 36570535 PMC: 9772611. DOI: 10.3389/fnagi.2022.1024415.

Serum uric acid level predicts the progression of amyotrophic lateral sclerosis following treatment with edaravone.

Han H, Shin H, Choi Y, Kim S, Kim S Redox Rep. 2022; 27(1):79-84.

PMID: 35296219 PMC: 8933037. DOI: 10.1080/13510002.2022.2051964.

References

Moher D, Liberati A, Tetzlaff J, Altman D . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009; 6(7):e1000097. PMC: 2707599. DOI: 10.1371/journal.pmed.1000097. View

Schrag M, Mueller C, Zabel M, Crofton A, Kirsch W, Ghribi O . Oxidative stress in blood in Alzheimer's disease and mild cognitive impairment: a meta-analysis. Neurobiol Dis. 2013; 59:100-10. DOI: 10.1016/j.nbd.2013.07.005. View

Stang A . Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010; 25(9):603-5. DOI: 10.1007/s10654-010-9491-z. View

Brown R, Al-Chalabi A . Amyotrophic Lateral Sclerosis. N Engl J Med. 2017; 377(2):162-172. DOI: 10.1056/NEJMra1603471. View

Paganoni S, Schwarzschild M . Urate as a Marker of Risk and Progression of Neurodegenerative Disease. Neurotherapeutics. 2016; 14(1):148-153. PMC: 5233635. DOI: 10.1007/s13311-016-0497-4. View

Keizman D, Ish-Shalom M, Berliner S, Maimon N, Vered Y, Artamonov I . Low uric acid levels in serum of patients with ALS: further evidence for oxidative stress?. J Neurol Sci. 2009; 285(1-2):95-9. DOI: 10.1016/j.jns.2009.06.002. View

Duan Y, Fan D . [Association of serum uric acid level with amyotrophic lateral sclerosis]. Zhonghua Yi Xue Za Zhi. 2016; 96(3):207-9. DOI: 10.3760/cma.j.issn.0376-2491.2016.03.012. View

Talbot K . Motor neuron disease: the bare essentials. Pract Neurol. 2009; 9(5):303-9. DOI: 10.1136/jnnp.2009.188151. View

Yin P, Lv H, Li Y, Meng Y, Zhang L, Tang P . The association between serum uric acid level and the risk of fractures: a systematic review and meta-analysis. Osteoporos Int. 2017; 28(8):2299-2307. DOI: 10.1007/s00198-017-4059-3. View

10.

Browne S, Yang L, DiMauro J, Fuller S, Licata S, Beal M . Bioenergetic abnormalities in discrete cerebral motor pathways presage spinal cord pathology in the G93A SOD1 mouse model of ALS. Neurobiol Dis. 2006; 22(3):599-610. DOI: 10.1016/j.nbd.2006.01.001. View

11.

OReilly E, Liu D, Johns D, Cudkowicz M, Paganoni S, Schwarzschild M . Serum urate at trial entry and ALS progression in EMPOWER. Amyotroph Lateral Scler Frontotemporal Degener. 2016; 18(1-2):120-125. PMC: 5531275. DOI: 10.1080/21678421.2016.1214733. View

12.

Marin B, Boumediene F, Logroscino G, Couratier P, Babron M, Leutenegger A . Variation in worldwide incidence of amyotrophic lateral sclerosis: a meta-analysis. Int J Epidemiol. 2016; 46(1):57-74. PMC: 5407171. DOI: 10.1093/ije/dyw061. View

13.

Ikeda K, Hirayama T, Takazawa T, Kawabe K, Iwasaki Y . Relationships between disease progression and serum levels of lipid, urate, creatinine and ferritin in Japanese patients with amyotrophic lateral sclerosis: a cross-sectional study. Intern Med. 2012; 51(12):1501-8. DOI: 10.2169/internalmedicine.51.7465. View

14.

Zoccolella S, Simone I, Capozzo R, Tortelli R, Leo A, DErrico E . An exploratory study of serum urate levels in patients with amyotrophic lateral sclerosis. J Neurol. 2010; 258(2):238-43. DOI: 10.1007/s00415-010-5735-9. View

15.

Nagase M, Yamamoto Y, Miyazaki Y, Yoshino H . Increased oxidative stress in patients with amyotrophic lateral sclerosis and the effect of edaravone administration. Redox Rep. 2015; 21(3):104-12. PMC: 6837462. DOI: 10.1179/1351000215Y.0000000026. View

16.

Chen X, Guo X, Huang R, Chen Y, Zheng Z, Shang H . Serum uric acid levels in patients with Alzheimer's disease: a meta-analysis. PLoS One. 2014; 9(4):e94084. PMC: 3979756. DOI: 10.1371/journal.pone.0094084. View

17.

Chowdhury R, Kunutsor S, Vitezova A, Oliver-Williams C, Chowdhury S, Kiefte-de-Jong J . Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies. BMJ. 2014; 348:g1903. PMC: 3972416. DOI: 10.1136/bmj.g1903. View

18.

Heath P, Shaw P . Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis. Muscle Nerve. 2002; 26(4):438-58. DOI: 10.1002/mus.10186. View

19.

Ames B, Cathcart R, Schwiers E, Hochstein P . Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci U S A. 1981; 78(11):6858-62. PMC: 349151. DOI: 10.1073/pnas.78.11.6858. View

20.

Kutzing M, Firestein B . Altered uric acid levels and disease states. J Pharmacol Exp Ther. 2007; 324(1):1-7. DOI: 10.1124/jpet.107.129031. View