Neuritic Plaques and Cerebrovascular Amyloid in Alzheimer Disease Are Antigenically Related

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1985 Dec 1

PMID 2934737

Citations 127

Authors

C W Wong

V Quaranta

G G Glenner

Affiliations

Soon will be listed here.

Abstract

A synthetic peptide (Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr), homologous to the amino terminus of a protein purified from cerebrovascular amyloid (beta protein), induced antibodies in BALB/c mice that were used immunohistochemically to stain not only amyloid-laden cerebral vessels but neuritic plaques as well. These findings suggest that the amyloid in neuritic plaques shares antigenic determinants with beta protein of cerebral vessels. Since the amino acid compositions of plaque amyloid and cerebrovascular amyloid are similar, it is likely that plaque amyloid also consists of beta protein. This possibility suggests a model for the pathogenesis of Alzheimer disease involving beta protein.

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References

Roth M, Tomlinson B, Blessed G . Correlation between scores for dementia and counts of 'senile plaques' in cerebral grey matter of elderly subjects. Nature. 1966; 209(5018):109-10. DOI: 10.1038/209109a0. View

Kidd M, Allsop D, Landon M . Senile plaque amyloid, paired helical filaments, and cerebrovascular amyloid in Alzheimer's disease are all deposits of the same protein. Lancet. 1985; 1(8423):278. DOI: 10.1016/s0140-6736(85)91054-2. View

Wisniewski H, Ghetti B, Terry R . Neuritic (senile) plaques and filamentous changes in aged rhesus monkeys. J Neuropathol Exp Neurol. 1973; 32(4):566-84. DOI: 10.1097/00005072-197310000-00007. View

Ishii T, Haga S . Immuno-electron microscopic localization of immunoglobulins in amyloid fibrils of senile plaques. Acta Neuropathol. 1976; 36(3):243-9. DOI: 10.1007/BF00685368. View

Costa P, Figueira A, Bravo F . Amyloid fibril protein related to prealbumin in familial amyloidotic polyneuropathy. Proc Natl Acad Sci U S A. 1978; 75(9):4499-503. PMC: 336143. DOI: 10.1073/pnas.75.9.4499. View

Glenner G . Congophilic microangiopathy in the pathogenesis of Alzheimer's syndrome (presenile dementia). Med Hypotheses. 1979; 5(11):1231-6. DOI: 10.1016/0306-9877(79)90005-7. View

Glenner G . Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). N Engl J Med. 1980; 302(23):1283-92. DOI: 10.1056/NEJM198006053022305. View

Glenner G . Amyloid deposits and amyloidosis: the beta-fibrilloses (second of two parts). N Engl J Med. 1980; 302(24):1333-43. DOI: 10.1056/NEJM198006123022403. View

Glenner G, Henry J, Fujihara S . Congophilic angiopathy in the pathogenesis of Alzheimer's degeneration. Ann Pathol. 1981; 1(2):120-9. View

10.

Shirahama T, Skinner M, Westermark P, Rubinow A, Cohen A, Brun A . Senile cerebral amyloid. Prealbumin as a common constituent in the neuritic plaque, in the neurofibrillary tangle, and in the microangiopathic lesion. Am J Pathol. 1982; 107(1):41-50. PMC: 1915994. View

11.

Green N, Alexander H, Olson A, Alexander S, Shinnick T, Sutcliffe J . Immunogenic structure of the influenza virus hemagglutinin. Cell. 1982; 28(3):477-87. DOI: 10.1016/0092-8674(82)90202-1. View

12.

Anderton B, Breinburg D, Downes M, Green P, Tomlinson B, Ulrich J . Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinants. Nature. 1982; 298(5869):84-6. DOI: 10.1038/298084a0. View

13.

Miyakawa T, Shimoji A, KURAMOTO R, Higuchi Y . The relationship between senile plaques and cerebral blood vessels in Alzheimer's disease and senile dementia. Morphological mechanism of senile plaque production. Virchows Arch B Cell Pathol Incl Mol Pathol. 1982; 40(2):121-9. DOI: 10.1007/BF02932857. View

14.

Allsop D, Landon M, Kidd M . The isolation and amino acid composition of senile plaque core protein. Brain Res. 1983; 259(2):348-52. DOI: 10.1016/0006-8993(83)91273-8. View

15.

Cohen D, Feiner H, Jensson O, Frangione B . Amyloid fibril in hereditary cerebral hemorrhage with amyloidosis (HCHWA) is related to the gastroentero-pancreatic neuroendocrine protein, gamma trace. J Exp Med. 1983; 158(2):623-8. PMC: 2187337. DOI: 10.1084/jem.158.2.623. View

16.

Hoffman J, Ericsson L, Eriksen N, Walsh K, BENDITT E . Murine tissue amyloid protein AA. NH2-terminal sequence identity with only one of two serum amyloid protein (ApoSAA) gene products. J Exp Med. 1984; 159(2):641-6. PMC: 2187226. DOI: 10.1084/jem.159.2.641. View

17.

Dwulet F, Benson M . Primary structure of an amyloid prealbumin and its plasma precursor in a heredofamilial polyneuropathy of Swedish origin. Proc Natl Acad Sci U S A. 1984; 81(3):694-8. PMC: 344901. DOI: 10.1073/pnas.81.3.694. View

18.

Glenner G, Wong C . Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun. 1984; 120(3):885-90. DOI: 10.1016/s0006-291x(84)80190-4. View

19.

Nakazato M, Kangawa K, Minamino N, Tawara S, Matsuo H, Araki S . Identification of a prealbumin variant in the serum of a Japanese patient with familial amyloidotic polyneuropathy. Biochem Biophys Res Commun. 1984; 122(2):712-8. DOI: 10.1016/s0006-291x(84)80092-3. View

20.

Glenner G, Wong C . Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem Biophys Res Commun. 1984; 122(3):1131-5. DOI: 10.1016/0006-291x(84)91209-9. View