Guanidinoacetic Acid and Creatine Are Associated with Cardiometabolic Risk Factors in Healthy Men and Women: A Cross-Sectional Study

Overview

Journal Nutrients

Date 2018 Jan 19

PMID 29342866

Citations 5

Authors

Sergej M Ostojic

Milan Vranes

Davor Loncar

Natasa Zenic

Damir Sekulic

Affiliations

Soon will be listed here.

Abstract

Guanidinoacetic acid (GAA) conversion to creatine is thought to be involved in cardiometabolic disturbances through its role in biological methylation and insulin secretion. We evaluated the association of serum GAA and creatine with cardiometabolic risk factors in a cohort of 151 apparently healthy adults (82 women and 69 men) aged 18-63 years. Serum levels of GAA and creatine were measured with liquid chromatography-tandem mass spectrometry. A multiple linear regression model adjusted for age and sex was employed to examine the relationship of serum GAA and creatine with cardiometabolic risk factors. Higher GAA levels were associated with an unfavorable cardiometabolic risk profile (higher insulin, higher total homocysteine, and higher body fat percentage), while having elevated serum creatine levels (≥31.1 µmol/L) was associated with being overweight (body mass index ≥ 25.0 kg/m). The results from our study suggest a possible role of the GAA-creatine axis in the pathogenesis of cardiovascular and metabolic diseases.

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