To the Brain and Back: Migratory Paths of Dendritic Cells in Multiple Sclerosis

Overview

Journal J Neuropathol Exp Neurol

Publisher Oxford University Press

Specialties Neurology
Pathology

Date 2018 Jan 18

PMID 29342287

Citations 20

Authors

Maxime De Laere

Zwi N Berneman

Nathalie Cools

Affiliations

Soon will be listed here.

Abstract

Migration of dendritic cells (DC) to the central nervous system (CNS) is a critical event in the pathogenesis of multiple sclerosis (MS). While up until now, research has mainly focused on the transmigration of DC through the blood-brain barrier, experimental evidence points out that also the choroid plexus and meningeal vessels represent important gateways to the CNS, especially in early disease stages. On the other hand, DC can exit the CNS to maintain immunological tolerance to patterns expressed in the CNS, a process that is perturbed in MS. Targeting trafficking of immune cells, including DC, to the CNS has demonstrated to be a successful strategy to treat MS. However, this approach is known to compromise protective immune surveillance of the brain. Unravelling the migratory paths of regulatory and pathogenic DC within the CNS may ultimately lead to the design of new therapeutic strategies able to selectively interfere with the recruitment of pathogenic DC to the CNS, while leaving host protective mechanisms intact.

Citing Articles

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