Respiratory Evaluation Through Volumetric Capnography Among Grade III Obese and Eutrophic Individuals: a Comparative Study

Overview

Journal Sao Paulo Med J

Specialty General Medicine

Date 2018 Jan 18

PMID 29340500

Citations 4

Authors

Debora Aparecida Oliveira Modena

Marcos Mello Moreira

Ilma Aparecida Paschoal

Monica Corso Pereira

Luiz Claudio Martins

Everton Cazzo

Elinton Adami Chaim

Affiliations

Soon will be listed here.

Abstract

Background: Excess trunk body fat in obese individuals influences respiratory physiological function. The aims of this study were to compare volumetric capnography findings (VCap) between severely obese patients and normal-weight subjects and to assess whether there is any association between neck circumference (NC), waist-hip ratio (WHR) and VCap among grade III obese individuals.

Design And Setting: Analytical observational case-matched cross-sectional study, University of Campinas.

Methods: This cross-sectional study compared VCap variables between 60 stage III obese patients and 60 normal-weight individuals.

Results: In comparison with the normal-weight group, obese patients presented higher alveolar minute volume (8.92 ± 4.94 versus 6.09 ± 2.2; P = < 0.0001), CO2 production (278 ± 91.0 versus 209 ± 60.23; P < 0.0001), expiratory tidal volume (807 ± 365 versus 624 ± 202; P = 0.005), CO2 production per breath (21.1 ± 9.7 versus 16.7 ± 6.16; P = 0.010) and peak expiratory flow (30.9 ± 11.9 versus 25.5 ± 9.13; P = 0.004). The end-expiratory CO2 (PetCO2) concentration (33.5 ± 4.88 versus 35.9 ± 3.79; P = 0.013) and the phase 3 slope were normalized according to expired tidal volume (0.02 ± 0.05 versus 0.03 ± 0.01; P = 0.049) were lower in the obese group.

Conclusions: The greater the NC was, the larger were the alveolar minute volume, anatomical dead space, CO2 production per minute and per breath and expiratory volume; whereas the smaller were the phase 2 slope (P2Slp), phase 3 slope (P3Slp) and pressure drop in the mouth during inspiration.

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