How Much Do We Know About Hemolytic Capability of Pathogenic Candida Species?

Overview

Journal Folia Microbiol (Praha)

Publisher Springer

Specialty Microbiology

Date 2018 Jan 17

PMID 29335820

Citations 8

Authors

Marcia C Furlaneto

Helena P Goes

Hugo F Perini

Renan C Dos Santos

Luciana Furlaneto-Maia

Affiliations

Soon will be listed here.

Abstract

Hemolytic factor production by pathogenic Candida species is considered an important attribute in promoting survival within the mammal host through the ability to assimilate iron from the hemoglobin-heme group. Hemolytic capability has been evaluated for Candida species based on hemolysis zones on plate assay, analysis of hemolytic activity in liquid culture medium, and hemolysis from cell-free culture broth. The production of hemolytic factor is variable among Candida species, where C. parapsilosis is the less hemolytic species. In general, no intraspecies differences in beta-hemolytic activities are found among isolates belonging to C. albicans, C. glabrata, C. krusei, C. tropicalis, and C. parapsilosis. The production of hemolytic factor by Candida species is affected by several factors such as glucose supplementation in the culture medium, blood source, presence of erythrocytes and hemoglobin, and presence of electrolytes. On the basis of existing achievements, more researches are still needed in order to extend our knowledge about the biochemical nature of hemolytic molecules produced by distinct Candida species, the mechanism of hemolysis, and the molecular basis of the hemolytic factor expression.

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