How Heart Rate Variability Affects Emotion Regulation Brain Networks

Overview

Journal Curr Opin Behav Sci

Date 2018 Jan 16

PMID 29333483

Citations 168

Authors

Mara Mather

Julian Thayer

Affiliations

Soon will be listed here.

Abstract

Individuals with high heart rate variability tend to have better emotional well-being than those with low heart rate variability, but the mechanisms of this association are not yet clear. In this paper, we propose the novel hypothesis that by inducing oscillatory activity in the brain, high amplitude oscillations in heart rate enhance functional connectivity in brain networks associated with emotion regulation. Recent studies using daily biofeedback sessions to increase the amplitude of heart rate oscillations suggest that high amplitude physiological oscillations have a causal impact on emotional well-being. Because blood flow timing helps determine brain network structure and function, slow oscillations in heart rate have the potential to strengthen brain network dynamics, especially in medial prefrontal regulatory regions that are particularly sensitive to physiological oscillations.

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References

Etkin A, Buchel C, Gross J . The neural bases of emotion regulation. Nat Rev Neurosci. 2015; 16(11):693-700. DOI: 10.1038/nrn4044. View

Silvani A, Calandra-Buonaura G, Benarroch E, Dampney R, Cortelli P . Bidirectional interactions between the baroreceptor reflex and arousal: an update. Sleep Med. 2015; 16(2):210-6. DOI: 10.1016/j.sleep.2014.10.011. View

Moore C, Cao R . The hemo-neural hypothesis: on the role of blood flow in information processing. J Neurophysiol. 2007; 99(5):2035-47. PMC: 3655718. DOI: 10.1152/jn.01366.2006. View

Ziegler G, Dahnke R, Yeragani V, Bar K . The relation of ventromedial prefrontal cortex activity and heart rate fluctuations at rest. Eur J Neurosci. 2010; 30(11):2205-10. DOI: 10.1111/j.1460-9568.2009.07008.x. View

Tan G, Dao T, Farmer L, Sutherland R, Gevirtz R . Heart rate variability (HRV) and posttraumatic stress disorder (PTSD): a pilot study. Appl Psychophysiol Biofeedback. 2010; 36(1):27-35. DOI: 10.1007/s10484-010-9141-y. View

Oneda B, Ortega K, Gusmao J, Araujo T, Mion Jr D . Sympathetic nerve activity is decreased during device-guided slow breathing. Hypertens Res. 2010; 33(7):708-12. DOI: 10.1038/hr.2010.74. View

Pfurtscheller G, Daly I, Bauernfeind G, Muller-Putz G . Coupling between intrinsic prefrontal HbO2 and central EEG beta power oscillations in the resting brain. PLoS One. 2012; 7(8):e43640. PMC: 3427164. DOI: 10.1371/journal.pone.0043640. View

Woodward S, Kaloupek D, Schaer M, Martinez C, Eliez S . Right anterior cingulate cortical volume covaries with respiratory sinus arrhythmia magnitude in combat veterans. J Rehabil Res Dev. 2008; 45(3):451-63. DOI: 10.1682/jrrd.2007.06.0082. View

Lakatos P, Shah A, Knuth K, Ulbert I, Karmos G, Schroeder C . An oscillatory hierarchy controlling neuronal excitability and stimulus processing in the auditory cortex. J Neurophysiol. 2005; 94(3):1904-11. DOI: 10.1152/jn.00263.2005. View

10.

Foster B, Parvizi J . Resting oscillations and cross-frequency coupling in the human posteromedial cortex. Neuroimage. 2012; 60(1):384-91. PMC: 3596417. DOI: 10.1016/j.neuroimage.2011.12.019. View

11.

Canolty R, Knight R . The functional role of cross-frequency coupling. Trends Cogn Sci. 2010; 14(11):506-15. PMC: 3359652. DOI: 10.1016/j.tics.2010.09.001. View

12.

Biswal B, Mennes M, Zuo X, Gohel S, Kelly C, Smith S . Toward discovery science of human brain function. Proc Natl Acad Sci U S A. 2010; 107(10):4734-9. PMC: 2842060. DOI: 10.1073/pnas.0911855107. View

13.

Peng C, Mietus J, Liu Y, Khalsa G, Douglas P, Benson H . Exaggerated heart rate oscillations during two meditation techniques. Int J Cardiol. 1999; 70(2):101-7. DOI: 10.1016/s0167-5273(99)00066-2. View

14.

Chang C, Glover G . Relationship between respiration, end-tidal CO2, and BOLD signals in resting-state fMRI. Neuroimage. 2009; 47(4):1381-93. PMC: 2721281. DOI: 10.1016/j.neuroimage.2009.04.048. View

15.

Sakaki M, Yoo H, Nga L, Lee T, Thayer J, Mather M . Heart rate variability is associated with amygdala functional connectivity with MPFC across younger and older adults. Neuroimage. 2016; 139:44-52. PMC: 5133191. DOI: 10.1016/j.neuroimage.2016.05.076. View

16.

Ottaviani C, Thayer J, Verkuil B, Lonigro A, Medea B, Couyoumdjian A . Physiological concomitants of perseverative cognition: A systematic review and meta-analysis. Psychol Bull. 2015; 142(3):231-259. DOI: 10.1037/bul0000036. View

17.

Paul M, Garg K . The effect of heart rate variability biofeedback on performance psychology of basketball players. Appl Psychophysiol Biofeedback. 2012; 37(2):131-44. DOI: 10.1007/s10484-012-9185-2. View

18.

Raupach T, Bahr F, Herrmann P, Luethje L, Heusser K, Hasenfuss G . Slow breathing reduces sympathoexcitation in COPD. Eur Respir J. 2008; 32(2):387-92. DOI: 10.1183/09031936.00109607. View

19.

Park H, Bernasconi F, Salomon R, Tallon-Baudry C, Spinelli L, Seeck M . Neural Sources and Underlying Mechanisms of Neural Responses to Heartbeats, and their Role in Bodily Self-consciousness: An Intracranial EEG Study. Cereb Cortex. 2017; 28(7):2351-2364. DOI: 10.1093/cercor/bhx136. View

20.

Vaschillo E, Vaschillo B, Lehrer P . Characteristics of resonance in heart rate variability stimulated by biofeedback. Appl Psychophysiol Biofeedback. 2006; 31(2):129-42. DOI: 10.1007/s10484-006-9009-3. View