T Lymphocyte Populations in Multiple Sclerosis

Overview

Journal Eur Arch Psychiatry Neurol Sci

Specialties Neurology
Psychiatry

Date 1985 Jan 1

PMID 2933259

Citations 2

Authors

U Rodeck

E Kuwert

H W Scharafinski

H J Lehmann

Affiliations

Soon will be listed here.

Abstract

In 36 patients representing different clinical stages of multiple sclerosis (MS) (9 patients with acute exacerbations; 21 patients in remission; 5 patients with chronic progressive MS) determinations of T lymphocyte populations using monoclonal antibodies against surface antigens (OKT3 (pan T cells), OKT4 (helper T cells), OKT8 (cytotoxic/suppressor T cells] were performed. Compared to the control group (40 healthy individuals) a clear elevation of the T4/T8 ratio was found in acute exacerbations and to a lesser degree in patients with inactive phases of MS. Patients with chronic progressive disease did not show increased T4/T8 ratios. Serial determination of lymphocyte populations after corticosteroid therapy in 10 selected patients revealed no significant changes which could be attributed to this therapeutic modality. Pathogenetic and clinical implications of the shifts in surface antigen expression of T lymphocyte populations mirroring the clinical course of MS are discussed.

Citing Articles

Detection of altered T helper 1 and T helper 2 cytokine production by peripheral blood mononuclear cells in patients with multiple sclerosis utilizing intracellular cytokine detection by flow cytometry and surface marker analysis.

Crucian B, Dunne P, Friedman H, Ragsdale R, Pross S, Widen R Clin Diagn Lab Immunol. 1996; 3(4):411-6.

PMID: 8807205 PMC: 170359. DOI: 10.1128/cdli.3.4.411-416.1996.

Alterations in levels of CD28-/CD8+ suppressor cell precursor and CD45RO+/CD4+ memory T lymphocytes in the peripheral blood of multiple sclerosis patients.

Crucian B, Dunne P, Friedman H, Ragsdale R, Pross S, Widen R Clin Diagn Lab Immunol. 1995; 2(2):249-52.

PMID: 7697540 PMC: 170139. DOI: 10.1128/cdli.2.2.249-252.1995.

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