Prognostic Factors of Noninvasive Mechanical Ventilation in Lung Cancer Patients with Acute Respiratory Failure

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2018 Jan 13

PMID 29329356

Citations 2

Authors

Wei-Chih Chen

Vincent Yi-Fong Su

Wen-Kuang Yu

Yen-Wen Chen

Kuang-Yao Yang

Affiliations

Soon will be listed here.

Abstract

Introduction: Few studies have reported outcomes of lung cancer patients with acute respiratory failure (RF) using noninvasive positive pressure ventilation (NIPPV). The aim of this study was to investigate the prognostic factors in these patients.

Materials And Methods: This retrospective observational study included all hospitalized lung cancer patients who received NIPPV for acute RF. It was conducted at a tertiary medical center in Taiwan from 2005 to 2010. The primary outcome was all cause mortality at 28 days after the initiation of NIPPV. Secondary outcomes included all-cause in-hospital mortality, weaning from NIPPV, intubation rate, tracheostomy rate, duration of NIPPV, hospital stay and intensive care unit stay.

Results: The all-cause mortality rate at day 28 of the enrolled 58 patients was 39.66%. The 90-day and 1-year mortality rates were 63.79% and 86.21%, respectively. NIPPV as the first line therapy for RF had higher 28-day mortality rate than it used for post-extubation RF (57.6% versus 16.0%, p<0.05). Independent predictors of mortality at 28 days were progressive disease or newly diagnosed lung cancer (OR 14.02 95% CI 1.03-191.59, p = 0.048), combined with other organ failure (OR 18.07 95% CI 1.87-172.7, p = 0.012), and NIPPV as the first line therapy for RF (OR 35.37 95% CI 3.30-378.68, p = 0.003).

Conclusion: Lung cancer patients using NIPPV with progressive or newly diagnosed cancer disease, combined with other organ failure, or NIPPV as the first line therapy for respiratory failure have a poor outcome.

Citing Articles

Non-invasive Mechanical Ventilation in Lung Cancer: Physiological Principles and Clinical Utilization in Surgical and Non-surgical Settings.

Cascella M, Esquinas A Thorac Res Pract. 2025; 26(1):32-39.

PMID: 39930750 PMC: 11784999. DOI: 10.4274/ThoracResPract.2024.23076.

Prognostic factors for advanced lung cancer patients with do-not-intubate order in intensive care unit: a retrospective study.

Shen C, Yang S, Chiu H, Chen W, Yu W, Yang K BMC Pulm Med. 2022; 22(1):245.

PMID: 35751074 PMC: 9229461. DOI: 10.1186/s12890-022-02042-7.

A combination of the APACHE II score, neutrophil/lymphocyte ratio, and expired tidal volume could predict non-invasive ventilation failure in pneumonia-induced mild to moderate acute respiratory distress syndrome patients.

Sun W, Luo Z, Cao Z, Wang J, Zhang L, Ma Y Ann Transl Med. 2022; 10(7):407.

PMID: 35530968 PMC: 9073780. DOI: 10.21037/atm-22-536.

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