Fanconi's Anemia: Terminal Leukemia and "Forme Fruste" in One Family

Overview

Journal Clin Genet

Specialty Genetics

Date 1979 Oct 1

PMID 293233

Citations 3

Authors

T M SCHROEDER

E Pohler

H D Hufnagl

Affiliations

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Abstract

Two adult sisters are described. One with a full clinical, hematological and cytogenetic picture of Fanconi's anemia died of monocytic leukemia. The other woman has several malformations and clinical signs which are found in Fanconi's anemia, but does not show any hematological disorder or sign of bone marrow insufficiency. Cytogenetic findings in this case are comparable to those typical cases with Fanconi's anemia. This case is therefore considered to represent a "forme fruste" of Fanconi's anemia.

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