Protective Effects of Salep Against Isoniazid Liver Toxicity in Wistar Rats

Overview

Journal J Tradit Complement Med

Specialty Rehabilitation Medicine

Date 2018 Jan 12

PMID 29322014

Citations 6

Authors

Hossein Kargar Jahromi

Morteza Pourahmad

Hassan Ali Abedi

Mohadeseh Karimi

Zahra Kargar Jahromi

Affiliations

Soon will be listed here.

Abstract

Introduction: Isoniazid is a drug for treatment of tuberculosis. One of the main side effects of this drug is hepatotoxicity, which is a major cause of treatment interruption in tuberculosis. This study is about the preventive effect of Salep on this side effect of isoniazid.

Materials And Methods: This study is an experimental study in which the preventive effect of salep on isoniazid hepatotoxicity is evaluated. In this study 56 rats were randomly placed in 7 eight members groups including: control group, sham, isoniazid and four isoniazid/salep groups. At the end of the study the laboratory criteria and histological features of liver toxicity were compared in different mentioned groups.

Results: Significant lower serum levels of liver enzymes, billirubin, MDA and TOC; and significant higher levels of TAC and total proteins, were revealed in isoniazid/salep group in compare to isoniazid alone group.In addition, histological studies had not showed liver injury in isoniazid/salep group, while there was significant liver injury in isoniazid alone group.

Conclusions: Orchid extract (salep), probably because of its antioxidant properties, prevent the destructive effects of isoniazid on the liver.

Citing Articles

Investigating the Preventive Effects of Oral Consumption of Dactylorhiza Maculate (Salep) Hydro-alcoholic Extract on Appetite and Body Weight in Male Rats.

Haghshenas H, Molayem M, Shafiei Jahromi N, Kargar Jahromi H, Dehghani M, Ebrahimi B Arch Razi Inst. 2024; 79(2):418-425.

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The effect of aqueous extract of orchid root on the structure of ovary and hypothalamic-pituitary-gonadal hormones in polycystic ovary syndrome rat model: An experimental study.

Abedi H, Zarrin-Mehr A, Ebrahimi B, Haghshenas H, Parvin N, Jahromi H Int J Reprod Biomed. 2024; 22(3):203-210.

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High methionine diet mediated oxidative stress and proteasome impairment causes toxicity in liver.

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Chitosan Microparticles Loaded with New Non-Cytotoxic Isoniazid Derivatives for the Treatment of Tuberculosis: In Vitro and In Vivo Studies.

Dragostin I, Dragostin O, Iacob A, Dragan M, Chitescu C, Confederat L Polymers (Basel). 2022; 14(12).

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