Inhibition of Aqueous Extracts of (AESN) on Oral Cancer Through Regulation of Mitochondrial Fission

Overview

Journal J Tradit Complement Med

Specialty Rehabilitation Medicine

Date 2018 Jan 12

PMID 29322012

Citations 7

Authors

Wu-Ching Uen

Bao-Hong Lee

Yeu-Ching Shi

She-Ching Wu

Chen-Jei Tai

Cheng-Jeng Tai

Affiliations

Soon will be listed here.

Abstract

The present study is designed to investigate the anti-oral cancer properties of on oral squamous cell carcinoma. is a Chinese herb used for suppression of various cancers. However, the inhibition of on oral cancer is unclear. Therefore, human oral squamous cancer cells (SCC)-4 were used to evaluate the effect of aqueous extracts of (AESN) on cancer cell proliferation, cell cycle, mitochondrial function and apoptosis. The SCC-4 cells were treated by AESN to evaluate the inhibition of cell proliferation and mitochondrial function . Our results suggested that AESN markedly increased reactive oxygen species production. AESN also promoted caspase-9 and caspase-3 activation and subsequent triggering of the mitochondrial apoptotic pathway. The inhibition of glucose uptake was alleviated mediated by a dose-dependent manner in SCC-4 cells with AESN treatment for 24 h, resulting in mitochondrial fission. These results suggested that AESN has potential to be used as a functional food in adjuvant chemotherapy for treating human oral cancer by suppression of mitochondrial function.

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