Modulation of Hippocampal Circuits by Muscarinic and Nicotinic Receptors

Overview

Journal Front Neural Circuits

Date 2018 Jan 12

PMID 29321728

Citations 47

Authors

Holger Dannenberg

Kimberly Young

Michael Hasselmo

Affiliations

Soon will be listed here.

Abstract

This article provides a review of the effects of activation of muscarinic and nicotinic receptors on the physiological properties of circuits in the hippocampal formation. Previous articles have described detailed computational hypotheses about the role of cholinergic neuromodulation in enhancing the dynamics for encoding in cortical structures and the role of reduced cholinergic modulation in allowing consolidation of previously encoded information. This article will focus on addressing the broad scope of different modulatory effects observed within hippocampal circuits, highlighting the heterogeneity of cholinergic modulation in terms of the physiological effects of activation of muscarinic and nicotinic receptors and the heterogeneity of effects on different subclasses of neurons.

Citing Articles

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