Semisynthesis and Biological Evaluation of Oleanolic Acid 3-O-β-d-Glucuronopyranoside Derivatives for Protecting H9c2 Cardiomyoblasts Against H₂O₂-Induced Injury

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2018 Jan 11

PMID 29320439

Citations 3

Authors

Yu Tian

Zhonghao Sun

Wenqian Wang

Hai Shang

Baoqi Wang

Di Deng

Guoxu Ma

Haifeng Wu

Nailiang Zhu

Xudong Xu

Guibo Sun

Xiaobo Sun

Affiliations

Soon will be listed here.

Abstract

A series of novel oleanolic acid 3---d-glucuronopyranoside derivatives have been designed and synthesized. Biological evaluation has indicated that some of the synthesized compounds exhibit moderate to good activity against H₂O₂-induced injury in rat myocardial cells (H9c2). Particularly, derivative 28--isobutyl ursolic amide 3---d-galactopyranoside () exhibited a greater protective effect than the positive control oleanolic acid 3---d-glucuronopyranoside, indicating that it possesses a great potential for further development as a cardiovascular disease modulator by structural modification.

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