Immune-Stimulatory and Therapeutic Activity of : Double-Edged Sword Against Salmonellosis

Overview

Journal J Immunol Res

Publisher Wiley

Specialty Allergy & Immunology

Date 2018 Jan 11

PMID 29318160

Citations 9

Authors

Sultan Alsuhaibani

Masood A Khan

Affiliations

Soon will be listed here.

Abstract

The present study was aimed at determining the activity of aqueous and methanolic extracts of (AETC and METC) against . anti- activity of was determined through the broth dilution and agar well diffusion assays. The immune-stimulating potential of AETC or METC was determined by measuring the cytokine levels in the culture supernatants of treated murine J774 macrophages. Antibacterial activity of AETC or METC was determined by treating infected macrophages and BALB/C mice. The toxicity of AETC or METC was determined by measuring the levels of liver inflammation markers aspartate transaminase (AST) and alanine transaminase (ALT) and antioxidant enzymes. Macrophages treated with AETC or METC secreted greater levels of IFN-, TNF-, and IL-1. METC showed greater activity against infection in macrophages and mice as well. Treatment with METC resulted in increased survival and reduced bacterial load in -infected mice. Moreover, METC or AETC treatment reduced the liver inflammation and rescued the levels of antioxidant enzymes in -infected mice. The results of the present study suggest that the use of may act as a double-edged sword in combating salmonellosis.

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