Quantification of Macular Vascular Density Using Optical Coherence Tomography Angiography and Its Relationship with Retinal Thickness in Myopic Eyes of Young Adults

Overview

Journal J Ophthalmol

Publisher Wiley

Specialty Ophthalmology

Date 2018 Jan 11

PMID 29318037

Citations 21

Authors

Shiqi Yang

Minwen Zhou

Bing Lu

Pengfei Zhang

Jingke Zhao

Mei Kang

Ruoshi Wang

Fenghua Wang

Xiaodong Sun

Affiliations

Soon will be listed here.

Abstract

Purpose: To quantify macular vascular density using optical coherence tomography angiography (OCTA) and to investigate its relationship with retinal thickness in myopic eyes of young adults.

Methods: In this cross-sectional study, 268 myopic eyes without pathological changes were recruited and divided into three groups: mild myopia ( = 81), moderate myopia ( = 117), and high myopia ( = 70). Macular vascular density was quantified by OCTA and compared among three groups. Average retinal thickness, central subfield thickness, and macular ganglion cell complex (mGCC) thickness were also evaluated and compared. Correlations among these variables were analyzed.

Results: There was no statistical difference in superficial (62.3 ± 5.7% versus 62.7 ± 5.9% versus 63.8 ± 5.5%) and deep macular vascular densities (58.3 ± 9.6% versus 59.2 ± 9.3% versus 60.9 ± 7.9%) among mild-myopia, moderate-myopia, and high-myopia groups (both > 0.05). Superficial and deep macular vascular densities both had correlations with mean arterial pressure. Furthermore, superficial macular vascular density was significantly correlated with mGCC thickness.

Conclusions: Varying degrees of myopia did not affect macular vascular density in young healthy adults. In addition, superficial macular vascular density, as an independent factor, was positively correlated with mGCC thickness.

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References

Wang Q, Chan S, Yang J, You B, Wang Y, Jonas J . Vascular Density in Retina and Choriocapillaris as Measured by Optical Coherence Tomography Angiography. Am J Ophthalmol. 2016; 168:95-109. DOI: 10.1016/j.ajo.2016.05.005. View

von Hanno T, Lade A, Mathiesen E, Peto T, Njolstad I, Bertelsen G . Macular thickness in healthy eyes of adults (N = 4508) and relation to sex, age and refraction: the Tromsø Eye Study (2007-2008). Acta Ophthalmol. 2016; 95(3):262-269. PMC: 5412929. DOI: 10.1111/aos.13337. View

Burgansky-Eliash Z, Lowenstein A, Neuderfer M, Kesler A, Barash H, Nelson D . The correlation between retinal blood flow velocity measured by the retinal function imager and various physiological parameters. Ophthalmic Surg Lasers Imaging Retina. 2013; 44(1):51-8. DOI: 10.3928/23258160-20121221-13. View

Quek T, Chua C, Chong C, Chong J, Hey H, Lee J . Prevalence of refractive errors in teenage high school students in Singapore. Ophthalmic Physiol Opt. 2003; 24(1):47-55. DOI: 10.1046/j.1475-1313.2003.00166.x. View

Song W, Lee S, Lee E, Kim C, Kim S . Macular thickness variations with sex, age, and axial length in healthy subjects: a spectral domain-optical coherence tomography study. Invest Ophthalmol Vis Sci. 2010; 51(8):3913-8. DOI: 10.1167/iovs.09-4189. View

Morgan I, Ohno-Matsui K, Saw S . Myopia. Lancet. 2012; 379(9827):1739-48. DOI: 10.1016/S0140-6736(12)60272-4. View

Wang X, Kong X, Jiang C, Li M, Yu J, Sun X . Is the peripapillary retinal perfusion related to myopia in healthy eyes? A prospective comparative study. BMJ Open. 2016; 6(3):e010791. PMC: 4800142. DOI: 10.1136/bmjopen-2015-010791. View

Pechauer A, Jia Y, Liu L, Gao S, Jiang C, Huang D . Optical Coherence Tomography Angiography of Peripapillary Retinal Blood Flow Response to Hyperoxia. Invest Ophthalmol Vis Sci. 2015; 56(5):3287-91. PMC: 4453965. DOI: 10.1167/iovs.15-16655. View

Kur J, Newman E, Chan-Ling T . Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease. Prog Retin Eye Res. 2012; 31(5):377-406. PMC: 3418965. DOI: 10.1016/j.preteyeres.2012.04.004. View

10.

Ueda K, Kanamori A, Akashi A, Tomioka M, Kawaka Y, Nakamura M . Effects of Axial Length and Age on Circumpapillary Retinal Nerve Fiber Layer and Inner Macular Parameters Measured by 3 Types of SD-OCT Instruments. J Glaucoma. 2015; 25(4):383-9. DOI: 10.1097/IJG.0000000000000216. View

11.

Akcay B, Gunay B, Kardes E, Unlu C, Ergin A . Evaluation of the Ganglion Cell Complex and Retinal Nerve Fiber Layer in Low, Moderate, and High Myopia: A Study by RTVue Spectral Domain Optical Coherence Tomography. Semin Ophthalmol. 2016; 32(6):682-688. DOI: 10.3109/08820538.2016.1170157. View

12.

Grzybowski A, Armesto A, Szwajkowska M, Iribarren G, Iribarren R . The Role of Atropine Eye Drops in Myopia Control. Curr Pharm Des. 2015; 21(32):4718-30. DOI: 10.2174/1381612821666150909095403. View

13.

Shahlaee A, Samara W, Hsu J, Say E, Khan M, Sridhar J . In Vivo Assessment of Macular Vascular Density in Healthy Human Eyes Using Optical Coherence Tomography Angiography. Am J Ophthalmol. 2016; 165:39-46. DOI: 10.1016/j.ajo.2016.02.018. View

14.

Rudnicka A, Kapetanakis V, Wathern A, Logan N, Gilmartin B, Whincup P . Global variations and time trends in the prevalence of childhood myopia, a systematic review and quantitative meta-analysis: implications for aetiology and early prevention. Br J Ophthalmol. 2016; 100(7):882-890. PMC: 4941141. DOI: 10.1136/bjophthalmol-2015-307724. View

15.

Liu L, Jia Y, Takusagawa H, Pechauer A, Edmunds B, Lombardi L . Optical Coherence Tomography Angiography of the Peripapillary Retina in Glaucoma. JAMA Ophthalmol. 2015; 133(9):1045-52. PMC: 4950955. DOI: 10.1001/jamaophthalmol.2015.2225. View

16.

Samara W, Shahlaee A, Adam M, Khan M, Chiang A, Maguire J . Quantification of Diabetic Macular Ischemia Using Optical Coherence Tomography Angiography and Its Relationship with Visual Acuity. Ophthalmology. 2016; 124(2):235-244. DOI: 10.1016/j.ophtha.2016.10.008. View

17.

Jin P, Zou H, Zhu J, Xu X, Jin J, Chang T . Choroidal and Retinal Thickness in Children With Different Refractive Status Measured by Swept-Source Optical Coherence Tomography. Am J Ophthalmol. 2016; 168:164-176. DOI: 10.1016/j.ajo.2016.05.008. View

18.

Benavente-Perez A, Hosking S, Logan N, Broadway D . Ocular blood flow measurements in healthy human myopic eyes. Graefes Arch Clin Exp Ophthalmol. 2010; 248(11):1587-94. DOI: 10.1007/s00417-010-1407-9. View

19.

Hollo G, Shu-Wei H, Naghizadeh F . Evaluation of a New Software Version of the RTVue Optical Coherence Tomograph for Image Segmentation and Detection of Glaucoma in High Myopia. J Glaucoma. 2015; 25(6):e615-9. DOI: 10.1097/IJG.0000000000000290. View

20.

Samara W, Shahlaee A, Sridhar J, Khan M, Ho A, Hsu J . Quantitative Optical Coherence Tomography Angiography Features and Visual Function in Eyes With Branch Retinal Vein Occlusion. Am J Ophthalmol. 2016; 166:76-83. DOI: 10.1016/j.ajo.2016.03.033. View