Role of MMP-1 (-519A/G, -1607 1G/2G), MMP-3 (Lys45Glu), MMP-7 (-181A/G), and MMP-12 (-82A/G) Variants and Plasma MMP Levels on Obesity-Related Phenotypes and Microvascular Reactivity in a Tunisian Population

Overview

Journal Dis Markers

Publisher Wiley

Specialty Biochemistry

Date 2018 Jan 11

PMID 29317790

Citations 6

Authors

Soumaya Boumiza

Sarra Bchir

Hela Ben Nasr

Ammar Abbassi

Marie-Paule Jacob

Xavier Norel

Zouhair Tabka

Karim Chahed

Affiliations

Soon will be listed here.

Abstract

Aims: The impact of MMP-1 (-519A/G, -1607 1G/2G), MMP-3 Lys45Glu (A/G), MMP-7 -181A/G, and MMP-12 -82A/G variants and plasma MMP levels on obesity and microvascular reactivity in Tunisians.

Methods: Our population included 202 nonobese and 168 obese subjects. Anthropometric, biochemical, and microvascular parameters were determined according to standard protocols. PCR-RFLP and ELISA were used to determine the genetic variants and levels of MMPs, respectively.

Results: The MMP-3 45Glu (G) allele associates with higher anthropometric values and MMP-3 levels compared to AA genotype carriers (BMI (kg/m): 30 ± 0.51 versus 27.33 ± 0.8, = 0.004; MMP-3 levels: 7.45 (4.77-11.91) versus 5.21 (3.60-10.21) ng/ml, = 0.006). The MMP-12 -82G allele was also associated with higher BMI values when compared to subjects carrying the AA genotype (31.41 ± 0.85 versus 28.76 ± 0.43, < 0.001). Individuals carrying the MMP-3 45G or MMP-12 -82G variants were also associated with a higher risk for severe forms of obesity (MMP-3: OR = 1.9, = 0.002; MMP-12: OR = 2.63, = 0.003). Similarly, the MMP-7 -181G allele was associated with a higher MMP-7 level and an increased risk for morbid obesity when compared to AA genotype carriers (0.32 (0.31-0.60) versus 0.18 (0.17-0.24) ng/ml, = 0.01; OR = 1.67, = 0.02, resp.).

Conclusion: MMP-3, MMP-7, and MMP-12 polymorphisms associate with obesity risk and its severity.

Citing Articles

Association of gene polymorphisms with breast cancer risk: A narrative review.

Akter T, Aziz M, Islam M, Sarwar M Health Sci Rep. 2023; 6(10):e1607.

PMID: 37841939 PMC: 10570771. DOI: 10.1002/hsr2.1607.

Roles of Matrix Metalloproteinases and Their Natural Inhibitors in Metabolism: Insights into Health and Disease.

Moliere S, Jaulin A, Tomasetto C, Dali-Youcef N Int J Mol Sci. 2023; 24(13).

PMID: 37445827 PMC: 10341707. DOI: 10.3390/ijms241310649.

The Modifying Effect of Obesity on the Association of Matrix Metalloproteinase Gene Polymorphisms with Breast Cancer Risk.

Pavlova N, Demin S, Churnosov M, Reshetnikov E, Aristova I, Churnosova M Biomedicines. 2022; 10(10).

PMID: 36289879 PMC: 9599943. DOI: 10.3390/biomedicines10102617.

MMPs and TIMPs levels are correlated with anthropometric parameters, blood pressure, and endothelial function in obesity.

Boumiza S, Chahed K, Tabka Z, Jacob M, Norel X, Ozen G Sci Rep. 2021; 11(1):20052.

PMID: 34625635 PMC: 8501083. DOI: 10.1038/s41598-021-99577-2.

Do different bariatric surgical procedures influence plasma levels of matrix metalloproteinase-2, -7, and -9 among patients with type 2 diabetes mellitus?.

Wu W, Lee W, Lee T, Chen S, Chen C World J Diabetes. 2020; 11(6):252-260.

PMID: 32547699 PMC: 7284017. DOI: 10.4239/wjd.v11.i6.252.

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