The Epidemiology of Prostate Cancer

Overview

Journal Cold Spring Harb Perspect Med

Specialty General Medicine

Date 2018 Jan 10

PMID 29311132

Citations 316

Authors

Claire H Pernar

Ericka M Ebot

Kathryn M Wilson

Lorelei A Mucci

Affiliations

Soon will be listed here.

Abstract

Prostate cancer is a major cause of disease and mortality among men, and each year 1.6 million men are diagnosed with and 366,000 men die of prostate cancer. In this review, we discuss the state of evidence for specific genetic, lifestyle, and dietary factors associated with prostate cancer risk. Given the biological heterogeneity of this cancer, we focus on risk factors for advanced or fatal prostate cancer. First, we provide descriptive epidemiology statistics and patterns for prostate cancer incidence and mortality around the world. This includes discussion of the impact of prostate-specific antigen screening on prostate cancer epidemiology. Next, we summarize evidence for selected risk factors for which there is strong or probable evidence of an association: genetics, obesity and weight change, physical activity, smoking, lycopene and tomatoes, fish, vitamin D and calcium, and statins. Finally, we highlight future directions for prostate cancer epidemiology research.

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References

Kristal A, Till C, Platz E, Song X, King I, Neuhouser M . Serum lycopene concentration and prostate cancer risk: results from the Prostate Cancer Prevention Trial. Cancer Epidemiol Biomarkers Prev. 2011; 20(4):638-46. PMC: 3070045. DOI: 10.1158/1055-9965.EPI-10-1221. View

Pantarotto J, Malone S, Dahrouge S, Gallant V, Eapen L . Smoking is associated with worse outcomes in patients with prostate cancer treated by radical radiotherapy. BJU Int. 2006; 99(3):564-9. DOI: 10.1111/j.1464-410X.2006.06656.x. View

Pischon T, Boeing H, Weikert S, Allen N, Key T, Johnsen N . Body size and risk of prostate cancer in the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomarkers Prev. 2008; 17(11):3252-61. DOI: 10.1158/1055-9965.EPI-08-0609. View

Cerhan J, Torner J, Lynch C, Rubenstein L, Lemke J, Cohen M . Association of smoking, body mass, and physical activity with risk of prostate cancer in the Iowa 65+ Rural Health Study (United States). Cancer Causes Control. 1997; 8(2):229-38. DOI: 10.1023/a:1018428531619. View

De Marzo A, Platz E, Sutcliffe S, Xu J, Gronberg H, Drake C . Inflammation in prostate carcinogenesis. Nat Rev Cancer. 2007; 7(4):256-69. PMC: 3552388. DOI: 10.1038/nrc2090. View

Vogt T, Mayne S, Graubard B, Swanson C, Sowell A, Schoenberg J . Serum lycopene, other serum carotenoids, and risk of prostate cancer in US Blacks and Whites. Am J Epidemiol. 2002; 155(11):1023-32. DOI: 10.1093/aje/155.11.1023. View

Travis R, Crowe F, Allen N, Appleby P, Roddam A, Tjonneland A . Serum vitamin D and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). Am J Epidemiol. 2009; 169(10):1223-32. PMC: 2675646. DOI: 10.1093/aje/kwp022. View

Meyer F, Bairati I, Fradet Y, Moore L . Dietary energy and nutrients in relation to preclinical prostate cancer. Nutr Cancer. 1997; 29(2):120-6. DOI: 10.1080/01635589709514612. View

Skinner H, Schwartz G . Serum calcium and incident and fatal prostate cancer in the National Health and Nutrition Examination Survey. Cancer Epidemiol Biomarkers Prev. 2008; 17(9):2302-5. PMC: 2760313. DOI: 10.1158/1055-9965.EPI-08-0365. View

10.

Mitrou P, Albanes D, Weinstein S, Pietinen P, Taylor P, Virtamo J . A prospective study of dietary calcium, dairy products and prostate cancer risk (Finland). Int J Cancer. 2007; 120(11):2466-73. DOI: 10.1002/ijc.22553. View

11.

Gilbert R, Metcalfe C, Fraser W, Donovan J, Hamdy F, Neal D . Associations of circulating 25-hydroxyvitamin D with prostate cancer diagnosis, stage and grade. Int J Cancer. 2011; 131(5):1187-96. PMC: 3378478. DOI: 10.1002/ijc.27327. View

12.

Mills P, Beeson W, Phillips R, Fraser G . Cohort study of diet, lifestyle, and prostate cancer in Adventist men. Cancer. 1989; 64(3):598-604. DOI: 10.1002/1097-0142(19890801)64:3<598::aid-cncr2820640306>3.0.co;2-6. View

13.

Li H, Stampfer M, Mucci L, Rifai N, Qiu W, Kurth T . A 25-year prospective study of plasma adiponectin and leptin concentrations and prostate cancer risk and survival. Clin Chem. 2009; 56(1):34-43. PMC: 2858593. DOI: 10.1373/clinchem.2009.133272. View

14.

Zhang J, Sasaki S, Amano K, Kesteloot H . Fish consumption and mortality from all causes, ischemic heart disease, and stroke: an ecological study. Prev Med. 1999; 28(5):520-9. DOI: 10.1006/pmed.1998.0472. View

15.

Chan J, Holick C, Leitzmann M, Rimm E, Willett W, Stampfer M . Diet after diagnosis and the risk of prostate cancer progression, recurrence, and death (United States). Cancer Causes Control. 2006; 17(2):199-208. DOI: 10.1007/s10552-005-0413-4. View

16.

Mucci L, Hjelmborg J, Harris J, Czene K, Havelick D, Scheike T . Familial Risk and Heritability of Cancer Among Twins in Nordic Countries. JAMA. 2016; 315(1):68-76. PMC: 5498110. DOI: 10.1001/jama.2015.17703. View

17.

Kenfield S, Stampfer M, Chan J, Giovannucci E . Smoking and prostate cancer survival and recurrence. JAMA. 2011; 305(24):2548-55. PMC: 3562349. DOI: 10.1001/jama.2011.879. View

18.

Allen N, Key T, Appleby P, Travis R, Roddam A, Tjonneland A . Animal foods, protein, calcium and prostate cancer risk: the European Prospective Investigation into Cancer and Nutrition. Br J Cancer. 2008; 98(9):1574-81. PMC: 2391107. DOI: 10.1038/sj.bjc.6604331. View

19.

Moreira D, Antonelli J, Presti Jr J, Aronson W, Terris M, Kane C . Association of cigarette smoking with interval to biochemical recurrence after radical prostatectomy: results from the SEARCH database. Urology. 2010; 76(5):1218-23. PMC: 3177236. DOI: 10.1016/j.urology.2010.01.066. View

20.

Barnett C, Nielson C, Shannon J, Chan J, Shikany J, Bauer D . Serum 25-OH vitamin D levels and risk of developing prostate cancer in older men. Cancer Causes Control. 2010; 21(8):1297-303. PMC: 2903686. DOI: 10.1007/s10552-010-9557-y. View