Replica Ornstein-Zernike Theory Applied for Studying the Equilibrium Distribution of Electrolytes Across Model Membranes

Overview

Journal J Phys Chem B

Publisher American Chemical Society

Specialty Chemistry

Date 2018 Jan 7

PMID 29304550

Authors

Barbara Hribar-Lee

Miha Luksic

Affiliations

Soon will be listed here.

Abstract

By means of replica Ornstein-Zernike theory (supplemented in a few cases by Monte Carlo simulations) we examined the distribution of an annealed primitive model +1:-1 electrolyte in a mixture with uncharged hard spheres, or another model +1:-1 or +2:-1 electrolyte inside and outside the quenched vesicles, decorated by a model membrane, and across the membrane phase. We explored the influence of the size and charge of the annealed fluid on the partition equilibrium, as well as the effect of the vesicle size and membrane interaction parameters (repulsive barrier height, attractive depth, and membrane width). A hydrophobic cation, present in the mixture with NaCl, slightly enhanced the concentration of sodium ions inside the model vesicle, compared to pure NaCl solution. The replica theory was in good agreement with computer simulations and as such adequate for studying partitioning of small and hydrophobic ions or hydrophobic solutes across model membranes.

References

Schamberger J, Clarke R . Hydrophobic ion hydration and the magnitude of the dipole potential. Biophys J. 2002; 82(6):3081-8. PMC: 1302096. DOI: 10.1016/S0006-3495(02)75649-X. View

Mingins J, Stigter D, Dill K . Phospholipid interactions in model membrane systems. I. Experiments on monolayers. Biophys J. 1992; 61(6):1603-15. PMC: 1260454. DOI: 10.1016/S0006-3495(92)81964-1. View

Stigter D, Mingins J, Dill K . Phospholipid interactions in model membrane systems. II. Theory. Biophys J. 1992; 61(6):1616-29. PMC: 1260455. DOI: 10.1016/S0006-3495(92)81965-3. View

Feigenson G . Phase boundaries and biological membranes. Annu Rev Biophys Biomol Struct. 2007; 36:63-77. PMC: 2642956. DOI: 10.1146/annurev.biophys.36.040306.132721. View

Chan Y, Boxer S . Model membrane systems and their applications. Curr Opin Chem Biol. 2007; 11(6):581-7. PMC: 2196400. DOI: 10.1016/j.cbpa.2007.09.020. View

Frolov V, Zimmerberg J . Membranes: Shaping biological matter. Nat Mater. 2009; 8(3):173-4. DOI: 10.1038/nmat2390. View

Vacha R, Berkowitz M, Jungwirth P . Molecular model of a cell plasma membrane with an asymmetric multicomponent composition: water permeation and ion effects. Biophys J. 2009; 96(11):4493-501. PMC: 2711485. DOI: 10.1016/j.bpj.2009.03.010. View

Chui J, Fyles T . Ionic conductance of synthetic channels: analysis, lessons, and recommendations. Chem Soc Rev. 2011; 41(1):148-75. DOI: 10.1039/c1cs15099e. View

Barboiu M, Gilles A . From natural to bioassisted and biomimetic artificial water channel systems. Acc Chem Res. 2013; 46(12):2814-23. DOI: 10.1021/ar400025e. View

10.

Hribar-Lee B . The application of the replica ornstein-zernike methodology for studying ionic membrane equilibria. Acta Chim Slov. 2013; 59(3):528-35. View

11.

Ketterer B, Neumcke B, Lauger P . Transport mechanism of hydrophobic ions through lipid bilayer membranes. J Membr Biol. 2013; 5(3):225-45. DOI: 10.1007/BF01870551. View

12.

Honig B, Hubbell W, Flewelling R . Electrostatic interactions in membranes and proteins. Annu Rev Biophys Biophys Chem. 1986; 15:163-93. DOI: 10.1146/annurev.bb.15.060186.001115. View

13.

Shen Y, Si W, Erbakan M, Decker K, De Zorzi R, Saboe P . Highly permeable artificial water channels that can self-assemble into two-dimensional arrays. Proc Natl Acad Sci U S A. 2015; 112(32):9810-5. PMC: 4538642. DOI: 10.1073/pnas.1508575112. View

14.

Shinoda W . Permeability across lipid membranes. Biochim Biophys Acta. 2016; 1858(10):2254-2265. DOI: 10.1016/j.bbamem.2016.03.032. View

15.

Koros W, Zhang C . Materials for next-generation molecularly selective synthetic membranes. Nat Mater. 2017; 16(3):289-297. DOI: 10.1038/nmat4805. View

16.

Jiang S, Li Y, Ladewig B . A review of reverse osmosis membrane fouling and control strategies. Sci Total Environ. 2017; 595:567-583. DOI: 10.1016/j.scitotenv.2017.03.235. View

17.

Flewelling R, Hubbell W . Hydrophobic ion interactions with membranes. Thermodynamic analysis of tetraphenylphosphonium binding to vesicles. Biophys J. 1986; 49(2):531-40. PMC: 1329493. DOI: 10.1016/S0006-3495(86)83663-3. View

18.

De Young L, Dill K . Solute partitioning into lipid bilayer membranes. Biochemistry. 1988; 27(14):5281-9. DOI: 10.1021/bi00414a050. View

19.

Flewelling R, Hubbell W . The membrane dipole potential in a total membrane potential model. Applications to hydrophobic ion interactions with membranes. Biophys J. 1986; 49(2):541-52. PMC: 1329494. DOI: 10.1016/S0006-3495(86)83664-5. View