Selenium: Implications for Outcomes in Extremely Preterm Infants

Overview

Journal J Perinatol

Specialty Gynecology & Obstetrics

Date 2018 Jan 5

PMID 29298985

Citations 22

Authors

Rachael Tindell

Trent Tipple

Affiliations

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Abstract

Extremely preterm infants are at high risk for morbidities including bronchopulmonary dysplasia, intraventricular hemorrhage, and retinopathy of prematurity likely related to their exposure to reactive oxygen and nitrogen species early in life. Selenium is a trace mineral contributes to the proper function of multiple systems including immunity, redox regulation, and inflammation via the "selenoenzymes" glutathione peroxidase, thioredoxin reductase, and selenoprotein P. Given that selenium accretion via the placenta occurs primarily during the third trimester, preterm neonates are born selenium deficient. While the role of selenium in animals and adults is better described, publications are lacking in the neonatal population regarding consequences of selenium deficiency or toxicity, accurate monitoring of levels, and proper enteral and parental dosages. This review highlights the role of selenium as it relates to the optimal function of antioxidant systems in extremely preterm infants in order to highlight the gaps in knowledge as it relates to the pathogenesis and prevention of morbidities in this population.

Citing Articles

Selenium Deficiency Exacerbates Hyperoxia-Induced Lung Injury in Newborn C3H/HeN Mice.

Bailey-Downs L, Sherlock L, Crossley M, Rivera Negron A, Pierce P, Wang S Antioxidants (Basel). 2024; 13(4).

PMID: 38671839 PMC: 11047402. DOI: 10.3390/antiox13040391.

Selenium in Infants and Preschool Children Nutrition: A Literature Review.

Dobrzynska M, Kaczmarek K, Przyslawski J, Drzymala-Czyz S Nutrients. 2023; 15(21).

PMID: 37960322 PMC: 10648445. DOI: 10.3390/nu15214668.

rs3877899 Variant Affects the Risk of Developing Advanced Stages of Retinopathy of Prematurity (ROP).

Strauss E, Januszkiewicz-Lewandowska D, Sobaniec A, Gotz-Wieckowska A Int J Mol Sci. 2023; 24(8).

PMID: 37108730 PMC: 10145309. DOI: 10.3390/ijms24087570.

Selenium status in term neonates, according to birth weight and gestational age, in relation to maternal hypertensive pathology.

Bizerea-Moga T, Pitulice L, Bizerea-Spiridon O, Angelescu C, Marginean O, Moga T Front Pediatr. 2023; 11:1157689.

PMID: 37063670 PMC: 10101720. DOI: 10.3389/fped.2023.1157689.

Neonatal Selenium Deficiency Decreases Selenoproteins in the Lung and Impairs Pulmonary Alveolar Development.

Sherlock L, McCarthy W, Grayck M, Solar M, Hernandez A, Zheng L Antioxidants (Basel). 2022; 11(12).

PMID: 36552625 PMC: 9774937. DOI: 10.3390/antiox11122417.

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