Lack of Effect of Graded Doses of Vitamin D on Bone Metabolism of Breastfed Infants

Overview

Journal J Clin Nutr Metab

Date 2018 Jan 3

PMID 29293697

Citations 3

Authors

Ekhard E Ziegler

Winston Wk Koo

Steven E Nelson

Janice M Jeter

Affiliations

Soon will be listed here.

Abstract

Objective: A range of doses of supplemental vitamin D has been shown to be effective in preventing rickets in breastfed infants, but the effect of different doses of vitamin D on bone metabolism and mineral content has not been delineated.

Methods: In a randomized trial, breastfed infants received from 2 to 9 months daily supplements of vitamin D in doses of 200 IU/d, 400 IU/d, 600 IU/d or 800 IU/d. Measures of bone metabolism (plasma) were determined periodically and bone mineral content (DXA) was determined at study entry and at the end of winter when infants were 5.5 to 9 months old. The main findings have been reported; here we report findings related to bone metabolism.

Results: There were no consistent meaningful effects of vitamin D dose on markers of bone metabolism. Some markers showed changes with age. Bone mineral content increased with age but showed no effect of vitamin D dose.

Conclusion: Vitamin D in daily doses from 200 IU/d to 800 IU/d had no measurable effect on bone mineral content or bone metabolism of breastfed infants.

Citing Articles

Effect of Oral Vitamin D3 Supplementation in Exclusively Breastfed Newborns: Prospective, Randomized, Double-Blind, Placebo-Controlled Trial.

Lin C, Lin C, Sung Y, Li S, Cheng B, Weng S J Bone Miner Res. 2022; 37(4):786-793.

PMID: 35122668 PMC: 9306990. DOI: 10.1002/jbmr.4521.

Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years of age.

Huey S, Acharya N, Silver A, Sheni R, Yu E, Pena-Rosas J Cochrane Database Syst Rev. 2020; 12:CD012875.

PMID: 33305842 PMC: 8121044. DOI: 10.1002/14651858.CD012875.pub2.

Vitamin D supplementation for term breastfed infants to prevent vitamin D deficiency and improve bone health.

Tan M, Abrams S, Osborn D Cochrane Database Syst Rev. 2020; 12:CD013046.

PMID: 33305822 PMC: 8812278. DOI: 10.1002/14651858.CD013046.pub2.

References

Abrams S, Hawthorne K, Rogers S, Hicks P, Carpenter T . Effects of ethnicity and vitamin D supplementation on vitamin D status and changes in bone mineral content in infants. BMC Pediatr. 2012; 12:6. PMC: 3271033. DOI: 10.1186/1471-2431-12-6. View

Ziegler E, Hollis B, Nelson S, Jeter J . Vitamin D deficiency in breastfed infants in Iowa. Pediatrics. 2006; 118(2):603-10. DOI: 10.1542/peds.2006-0108. View

Holick M . Vitamin D deficiency. N Engl J Med. 2007; 357(3):266-81. DOI: 10.1056/NEJMra070553. View

Koo W, Hammami M, Hockman E . Use of fan beam dual energy x-ray absorptiometry to measure body composition of piglets. J Nutr. 2002; 132(6):1380-3. DOI: 10.1093/jn/132.6.1380. View

Wagner C, Hulsey T, Fanning D, Ebeling M, Hollis B . High-dose vitamin D3 supplementation in a cohort of breastfeeding mothers and their infants: a 6-month follow-up pilot study. Breastfeed Med. 2007; 1(2):59-70. DOI: 10.1089/bfm.2006.1.59. View

Hammami M, Koo W, Hockman E . Technical considerations for fan-beam dual-energy x-ray absorptiometry body composition measurements in pediatric studies. JPEN J Parenter Enteral Nutr. 2004; 28(5):328-33. DOI: 10.1177/0148607104028005328. View

Gartner L, Greer F . Prevention of rickets and vitamin D deficiency: new guidelines for vitamin D intake. Pediatrics. 2003; 111(4 Pt 1):908-10. DOI: 10.1542/peds.111.4.908. View

Hollis B, Pittard 3rd W, Reinhardt T . Relationships among vitamin D, 25-hydroxyvitamin D, and vitamin D-binding protein concentrations in the plasma and milk of human subjects. J Clin Endocrinol Metab. 1986; 62(1):41-4. DOI: 10.1210/jcem-62-1-41. View

Ala-Houhala M, Koskinen T, Parviainen M, VISAKORPI J . 25-Hydroxyvitamin D and vitamin D in human milk: effects of supplementation and season. Am J Clin Nutr. 1988; 48(4):1057-60. DOI: 10.1093/ajcn/48.4.1057. View

10.

Ziegler E, Nelson S, Jeter J . Vitamin D supplementation of breastfed infants: a randomized dose-response trial. Pediatr Res. 2014; 76(2):177-83. PMC: 4104134. DOI: 10.1038/pr.2014.76. View

11.

Chauhan S, Koo W, Hammami M, Hockman E . Fan beam dual energy X-ray absorptiometry body composition measurements in piglets. J Am Coll Nutr. 2003; 22(5):408-14. DOI: 10.1080/07315724.2003.10719324. View

12.

Park M, Namgung R, Kim D, Tsang R . Bone mineral content is not reduced despite low vitamin D status in breast milk-fed infants versus cow's milk based formula-fed infants. J Pediatr. 1998; 132(4):641-5. DOI: 10.1016/s0022-3476(98)70353-1. View

13.

Specker B, Tsang R, Hollis B . Effect of race and diet on human-milk vitamin D and 25-hydroxyvitamin D. Am J Dis Child. 1985; 139(11):1134-7. DOI: 10.1001/archpedi.1985.02140130072032. View

14.

Greer F, Searcy J, Levin R, Steichen J, Tsang R . Bone mineral content and serum 25-hydroxyvitamin D concentrations in breast-fed infants with and without supplemental vitamin D: one-year follow-up. J Pediatr. 1982; 100(6):919-22. DOI: 10.1016/s0022-3476(82)80514-3. View

15.

Gallo S, Comeau K, Vanstone C, Agellon S, Sharma A, Jones G . Effect of different dosages of oral vitamin D supplementation on vitamin D status in healthy, breastfed infants: a randomized trial. JAMA. 2013; 309(17):1785-92. DOI: 10.1001/jama.2013.3404. View

16.

Koo W, Massom L, Walters J . Validation of accuracy and precision of dual energy X-ray absorptiometry for infants. J Bone Miner Res. 1995; 10(7):1111-5. DOI: 10.1002/jbmr.5650100716. View

17.

Greer F, Marshall S . Bone mineral content, serum vitamin D metabolite concentrations, and ultraviolet B light exposure in infants fed human milk with and without vitamin D2 supplements. J Pediatr. 1989; 114(2):204-12. DOI: 10.1016/s0022-3476(89)80784-x. View