Testing Drug Combinations to Slow Aging

Overview

Journal Pathobiol Aging Age Relat Dis

Specialty Geriatrics

Date 2018 Jan 2

PMID 29291036

Citations 4

Authors

Warren Ladiges

Denny Liggitt

Affiliations

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Citing Articles

Pharmaceutical interventions to slow human aging. Are we ready for cocktails?.

Rosenfeld M, Ladiges W Aging Pathobiol Ther. 2022; 4(2):51-52.

PMID: 36082207 PMC: 9450580. DOI: 10.31491/apt.2022.06.086.

Short term treatment with a cocktail of rapamycin, acarbose and phenylbutyrate delays aging phenotypes in mice.

Jiang Z, Wang J, Imai D, Snider T, Klug J, Mangalindan R Sci Rep. 2022; 12(1):7300.

PMID: 35508491 PMC: 9067553. DOI: 10.1038/s41598-022-11229-1.

A Geroscience Approach to Preventing Pathologic Consequences of COVID-19.

Dou Y, Fatemi S, Darvas M, Gale Jr M, Ladiges W J Interferon Cytokine Res. 2020; 40(9):433-437.

PMID: 32790488 PMC: 7645979. DOI: 10.1089/jir.2020.29018.dou.

Pairwise combinations of chemical compounds that delay yeast chronological aging through different signaling pathways display synergistic effects on the extent of aging delay.

Dakik P, McAuley M, Chancharoen M, Mitrofanova D, Rodriguez M, Junio J Oncotarget. 2019; 10(3):313-338.

PMID: 30719227 PMC: 6349451. DOI: 10.18632/oncotarget.26553.

References

Niedernhofer L, Kirkland J, Ladiges W . Molecular pathology endpoints useful for aging studies. Ageing Res Rev. 2016; 35:241-249. PMC: 5357461. DOI: 10.1016/j.arr.2016.09.012. View

Szeto H . First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics. Br J Pharmacol. 2013; 171(8):2029-50. PMC: 3976620. DOI: 10.1111/bph.12461. View

Ladiges W, Snyder J, Wilkinson E, Imai D, Snider T, Ge X . A New Preclinical Paradigm for Testing Anti-Aging Therapeutics. J Gerontol A Biol Sci Med Sci. 2017; 72(6):760-762. PMC: 6075196. DOI: 10.1093/gerona/glx019. View

Wilkinson J, Burmeister L, Brooks S, Chan C, Friedline S, Harrison D . Rapamycin slows aging in mice. Aging Cell. 2012; 11(4):675-82. PMC: 3434687. DOI: 10.1111/j.1474-9726.2012.00832.x. View

Ladiges W . The quality control theory of aging. Pathobiol Aging Age Relat Dis. 2014; 4. PMC: 4033319. DOI: 10.3402/pba.v4.24835. View

Harrison D, Strong R, Allison D, Ames B, Astle C, Atamna H . Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell. 2013; 13(2):273-82. PMC: 3954939. DOI: 10.1111/acel.12170. View

Dai D, Chen T, Szeto H, Nieves-Cintron M, Kutyavin V, Santana L . Mitochondrial targeted antioxidant Peptide ameliorates hypertensive cardiomyopathy. J Am Coll Cardiol. 2011; 58(1):73-82. PMC: 3742010. DOI: 10.1016/j.jacc.2010.12.044. View

Szeto H, Birk A . Serendipity and the discovery of novel compounds that restore mitochondrial plasticity. Clin Pharmacol Ther. 2014; 96(6):672-83. PMC: 4267688. DOI: 10.1038/clpt.2014.174. View

Ladiges W, Ikeno Y, Niedernhofer L, McIndoe R, Ciol M, Ritchey J . The Geropathology Research Network: An Interdisciplinary Approach for Integrating Pathology Into Research on Aging. J Gerontol A Biol Sci Med Sci. 2015; 71(4):431-4. PMC: 5014185. DOI: 10.1093/gerona/glv079. View

10.

Flynn J, OLeary M, Zambataro C, Academia E, Presley M, Garrett B . Late-life rapamycin treatment reverses age-related heart dysfunction. Aging Cell. 2013; 12(5):851-62. PMC: 4098908. DOI: 10.1111/acel.12109. View